| Literature DB >> 12781188 |
Michael D Urbaniak1, Lisa M Frost, John P Bingham, Lloyd R Kelland, John A Hartley, Derek N Woolfson, Stephen Caddick.
Abstract
Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.Entities:
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Year: 2003 PMID： 12781188 DOI： 10.1016/s0960-894x(03)00328-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823