Literature DB >> 12781178

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Stefan Jaroch1, Peter Hölscher, Hartmut Rehwinkel, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald.   

Abstract

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.

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Year:  2003        PMID： 12781178     DOI： 10.1016/s0960-894x(03)00351-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Nitrenium ion azaspirocyclization-spirodienone cleavage: a new synthetic strategy for the stereocontrolled preparation of highly substituted lactams and N-hydroxy lactams.

Authors:  Duncan J Wardrop; Matthew S Burge
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

Review 2.  Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Authors:  Paramita Mukherjee; Maris A Cinelli; Soosung Kang; Richard B Silverman
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

3.  Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Authors:  Maris A Cinelli; Huiying Li; Georges Chreifi; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2014-02-10       Impact factor: 7.446
  3 in total

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