Literature DB >> 12781173

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.

Robert Aslanian1, Mwangi wa Mutahi, Neng-Yang Shih, John J Piwinski, Robert West, Shirley M Williams, Susan She, Ren-Long Wu, John A Hey.   

Abstract

Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.

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Year:  2003        PMID: 12781173     DOI: 10.1016/s0960-894x(03)00357-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.

Authors:  Rita Capela; Ghislain G Cabal; Philip J Rosenthal; Jiri Gut; Maria M Mota; Rui Moreira; Francisca Lopes; Miguel Prudêncio
Journal:  Antimicrob Agents Chemother       Date:  2011-08-01       Impact factor: 5.191

Review 2.  Roles of histamine and its receptors in allergic and inflammatory bowel diseases.

Authors:  Hua Xie; Shao-Heng He
Journal:  World J Gastroenterol       Date:  2005-05-21       Impact factor: 5.742

  2 in total

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