Literature DB >> 12779090

Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells.

Partha P Manna1, Andrés Jaramillo, Kanchana Majumder, Lacey G Campbell, Timothy P Fleming, Jill R Dietz, John F Dipersio, T Mohanakumar.   

Abstract

Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

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Year:  2003        PMID： 12779090     DOI： 10.1023/a:1023323509888

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  6 in total

1.  Identification of immunodominant HLA-B7-restricted CD8+ cytotoxic T cell epitopes derived from mammaglobin-A expressed on human breast cancers.

Authors:  Haseeb Ilias Basha; Venkataswarup Tiriveedhi; Timothy P Fleming; William E Gillanders; T Mohanakumar
Journal:  Breast Cancer Res Treat       Date:  2010-06-11       Impact factor: 4.872

2.  Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.

Authors:  Lijin Li; John M Herndon; Steven M Truscott; Ted H Hansen; Timothy P Fleming; Peter Goedegebuure; William E Gillanders
Journal:  Vaccine       Date:  2010-02-23       Impact factor: 3.641

3.  Identification and translational validation of novel mammaglobin-A CD8 T cell epitopes.

Authors:  S D Soysal; S Muenst; J Kan-Mitchell; E Huarte; X Zhang; I Wilkinson-Ryan; T Fleming; V Tiriveedhi; T Mohanakumar; L Li; J Herndon; D Oertli; S P Goedegebuure; W E Gillanders
Journal:  Breast Cancer Res Treat       Date:  2014-09-12       Impact factor: 4.872

4.  Recombinant mammaglobin A adenovirus-infected dendritic cells induce mammaglobin A-specific CD8+ cytotoxic T lymphocytes against breast cancer cells in vitro.

Authors:  Huixia Cui; Wenlu Zhang; Wei Hu; Kun Liu; Tong Wang; Nan Ma; Xiaohui Liu; Yunpeng Liu; Youhong Jiang
Journal:  PLoS One       Date:  2013-05-01       Impact factor: 3.240

5.  Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies.

Authors:  Menelaos Zafrakas; Beate Petschke; Andreas Donner; Florian Fritzsche; Glen Kristiansen; Ruth Knüchel; Edgar Dahl
Journal:  BMC Cancer       Date:  2006-04-09       Impact factor: 4.430

Review 6.  Human mammaglobin in breast cancer: a brief review of its clinical utility.

Authors:  Fawwaz Shakir Al Joudi
Journal:  Indian J Med Res       Date:  2014-05       Impact factor: 2.375
  6 in total

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