AIM: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. METHODS: The effects of a single dose of malathion [240 mg/kg (1/12 LD(50))] on plasma acetylcholinesterase (ACE) activity, spermatozoa (epididymal cauda counts and teratozoospermia), testis and plasma testosterone concentration) were evaluated at day 1, 8, 16, 35 and 40 after treatment. RESULTS: The sperm count was decreased significantly 24 h after treatment and teratozoospermia was increased at day 35 and 40. The height of the seminiferous epithelium and the diameter of tubular lumen were decreased at day 8. The percentage of tubular blockade was increased between day 8 and 35. A decrease in testosterone plasma level was observed at day 16 after treatment. CONCLUSION: Malathion damages male reproduction. The depletion of seminiferous tubules and the increase in teratozoospermia may be a genotoxic damage to the renewing spermatogonia, but the possibility of spermatogenic/spermiogenic disfunction due to a decrease in the plasma testosterone level can not be ruled out.
AIM: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. METHODS: The effects of a single dose of malathion [240 mg/kg (1/12 LD(50))] on plasma acetylcholinesterase (ACE) activity, spermatozoa (epididymal cauda counts and teratozoospermia), testis and plasma testosterone concentration) were evaluated at day 1, 8, 16, 35 and 40 after treatment. RESULTS: The sperm count was decreased significantly 24 h after treatment and teratozoospermia was increased at day 35 and 40. The height of the seminiferous epithelium and the diameter of tubular lumen were decreased at day 8. The percentage of tubular blockade was increased between day 8 and 35. A decrease in testosterone plasma level was observed at day 16 after treatment. CONCLUSION:Malathion damages male reproduction. The depletion of seminiferous tubules and the increase in teratozoospermia may be a genotoxic damage to the renewing spermatogonia, but the possibility of spermatogenic/spermiogenic disfunction due to a decrease in the plasma testosterone level can not be ruled out.
Authors: Maria Adamkovicova; Robert Toman; Michal Cabaj; Peter Massanyi; Monika Martiniakova; Radoslav Omelka; Vladimira Krajcovicova; Hana Duranova Journal: ScientificWorldJournal Date: 2014-12-07
Authors: Luc Multigner; Philippe Kadhel; Michel Pascal; Farida Huc-Terki; Henri Kercret; Catherine Massart; Eustase Janky; Jacques Auger; Bernard Jégou Journal: Environ Health Date: 2008-07-30 Impact factor: 5.984