| Literature DB >> 12778125 |
Derek M Dykxhoorn1, Carl D Novina, Phillip A Sharp.
Abstract
Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.Mesh：
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Year: 2003 PMID： 12778125 DOI： 10.1038/nrm1129
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444