BACKGROUND: The anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder. AIMS: To examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness. METHOD: Magnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features. RESULTS: Compared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness. CONCLUSIONS: Although ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.
BACKGROUND: The anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder. AIMS: To examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness. METHOD: Magnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features. RESULTS: Compared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness. CONCLUSIONS: Although ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.
Authors: Tim B Ziermans; Patricia F Schothorst; Hugo G Schnack; P Cédric M P Koolschijn; René S Kahn; Herman van Engeland; Sarah Durston Journal: Schizophr Bull Date: 2010-10-07 Impact factor: 9.306
Authors: Alex Fornito; Murat Yücel; Stephen J Wood; Chris Adamson; Dennis Velakoulis; Michael M Saling; Patrick D McGorry; Christos Pantelis Journal: Hum Brain Mapp Date: 2008-04 Impact factor: 5.038
Authors: Sarah Whittle; Marie B H Yap; Murat Yücel; Alex Fornito; Julian G Simmons; Anna Barrett; Lisa Sheeber; Nicholas B Allen Journal: Proc Natl Acad Sci U S A Date: 2008-02-25 Impact factor: 11.205
Authors: Alex Fornito; Stephen J Wood; Sarah Whittle; Jack Fuller; Chris Adamson; Michael M Saling; Dennis Velakoulis; Christos Pantelis; Murat Yücel Journal: Hum Brain Mapp Date: 2008-02 Impact factor: 5.038
Authors: Wi Hoon Jung; June Sic Kim; Joon Hwan Jang; Jung-Seok Choi; Myung Hun Jung; Ji-Young Park; Ji Yeon Han; Chi-Hoon Choi; Do-Hyung Kang; Chun Kee Chung; Jun Soo Kwon Journal: Schizophr Bull Date: 2009-12-21 Impact factor: 9.306
Authors: Min Soo Byun; Jung-Seok Choi; So Young Yoo; Do-Hyung Kang; Chi-Hoon Choi; Dong Pyo Jang; Wi Hoon Jung; Myung Hun Jung; Joon Hwan Jang; Jong-Min Lee; Jun Soo Kwon Journal: Psychiatry Investig Date: 2009-11-21 Impact factor: 2.505