Literature DB >> 12776228

Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD).

J S H Vles1, F J M Feron, J G M Hendriksen, J Jolles, M J P G van Kroonenburgh, W E J Weber.   

Abstract

Adults suffering from Attention Deficit Hyperactivity Disorder (ADHD) are known to have disturbed central dopaminergic transmission. With Single Photon Emission Computed Tomography (SPECT) we studied brain dopamine transporter and receptor activity in six boys with ADHD. Three months after initiation of treatment with methylphenidate we found a down-regulation of the post-synaptic dopamine receptor with a maximum of 20 % and a down-regulation of the dopamine transporter with a maximum of 74.7 % in the striatal system. This corresponded to a positive clinical response evaluated by neuropsychological questionnaires and tests. We suggest that dopamine transporter imaging by SPECT might be used to monitor psychostimulant treatment in children suffering from ADHD.

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Year:  2003        PMID： 12776228     DOI： 10.1055/s-2003-39602

Source DB:  PubMed          Journal:  Neuropediatrics        ISSN： 0174-304X            Impact factor:   1.947


  22 in total

1.  Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro.

Authors:  A G Ludolph; U Schaz; A Storch; S Liebau; J M Fegert; T M Boeckers
Journal:  J Neural Transm (Vienna)       Date:  2006-06-01       Impact factor: 3.575

2.  Long-term exposure to oral methylphenidate or dl-amphetamine mixture in peri-adolescent rhesus monkeys: effects on physiology, behavior, and dopamine system development.

Authors:  Paul L Soto; Kristin M Wilcox; Yun Zhou; Anil Kumar; Nancy A Ator; Mark A Riddle; Dean F Wong; Michael R Weed
Journal:  Neuropsychopharmacology       Date:  2012-07-18       Impact factor: 7.853

3.  The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.

Authors:  Mark A Bellgrove; Katharina Domschke; Ziarih Hawi; Aiveen Kirley; Celine Mullins; Ian H Robertson; Michael Gill
Journal:  Exp Brain Res       Date:  2005-01-15       Impact factor: 1.972

Review 4.  Pharmacologic treatment of attention-deficit/hyperactivity disorder: efficacy, safety and mechanisms of action.

Authors:  Steven R Pliszka
Journal:  Neuropsychol Rev       Date:  2007-03       Impact factor: 7.444

5.  Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat.

Authors:  Bin Tang; Nachum Dafny
Journal:  Eur J Pharmacol       Date:  2012-09-18       Impact factor: 4.432

6.  Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET.

Authors:  Kristin M Wilcox; Yun Zhou; Dean F Wong; Mohab Alexander; Arman Rahmim; John Hilton; Michael R Weed
Journal:  Synapse       Date:  2008-12       Impact factor: 2.562

Review 7.  Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs.

Authors:  Jan Booij; Paul Kemp
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-10-30       Impact factor: 9.236

8.  Neurological correlates of reward responding in adolescents with and without externalizing behavior disorders.

Authors:  Lisa M Gatzke-Kopp; Theodore P Beauchaine; Katherine E Shannon; Jane Chipman; Andrew P Fleming; Sheila E Crowell; Olivia Liang; L Clark Johnson; Elizabeth Aylward
Journal:  J Abnorm Psychol       Date:  2009-02

9.  Neuroligin modulates the locomotory dopaminergic and serotonergic neuronal pathways of C. elegans.

Authors:  Patricia G Izquierdo; Fernando Calahorro; Manuel Ruiz-Rubio
Journal:  Neurogenetics       Date:  2013-10-08       Impact factor: 2.660

10.  Comorbidities and continuities as ontogenic processes: toward a developmental spectrum model of externalizing psychopathology.

Authors:  Theodore P Beauchaine; Tiffany McNulty
Journal:  Dev Psychopathol       Date:  2013-11
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