Literature DB >> 12775893

Nature's best weapons to fight cancer. Revival of human monoclonal IgM antibodies.

H Peter Vollmers1, Stephanie Brändlein.   

Abstract

The unique features of monoclonal antibodies (specificity, effectiveness, purity and unlimited reproducibility) make them ideal tools for the specific treatment of all kind of diseases. The third generation of monoclonal antibodies for the treatment of human diseases will be, after murine and "humanised" murine immunoglobulins, fully human antibodies. The best source of human monoclonal antibodies are the antibody pools of cancer patients themselves with the best technique for generating them being conventional human hybridoma technology. This technique, will generate human monoclonal antibodies which will not only define important new targets on cancerous tissue, but will also provide the necessary therapeutic human antibodies in the fight against cancer.

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Year:  2002        PMID: 12775893

Source DB:  PubMed          Journal:  Hum Antibodies        ISSN: 1093-2607


  6 in total

Review 1.  Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer.

Authors:  Trisha A Rettig; Julie N Harbin; Adelaide Harrington; Leonie Dohmen; Sherry D Fleming
Journal:  Clin Immunol       Date:  2015-07-02       Impact factor: 3.969

2.  The novel panel assay to define tumor-associated antigen-binding antibodies in patients with metastatic melanomas may have diagnostic value.

Authors:  Beatrix Kotlan; Gabriella Liszkay; Miri Blank; Orsolya Csuka; Timea Balatoni; Laszlo Toth; Klara Eles; Szabolcs Horvath; Gyorgy Naszados; Judit Olasz; Balazs Banky; Jozsef Toth; Maria Godeny; Francesco M Marincola; Miklos Kasler; Yehuda Shoenfeld
Journal:  Immunol Res       Date:  2015-02       Impact factor: 2.829

3.  The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering.

Authors:  Kenneth W Walker; Ian N Foltz; Tina Wang; Hossein Salimi-Moosavi; Julie M Bailis; Fei Lee; Phillip An; Stephen Smith; Richele Bruno; Zhulun Wang
Journal:  J Biol Chem       Date:  2020-06-09       Impact factor: 5.157

Review 4.  Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases.

Authors:  Brent J Ryan; Ahuva Nissim; Paul G Winyard
Journal:  Redox Biol       Date:  2014-05-28       Impact factor: 11.799

5.  L2pB1 Cells Contribute to Tumor Growth Inhibition.

Authors:  Varuna Shibad; Ali Bootwala; Changchuin Mao; Hanna Bader; Hung Vo; Esther Landesman-Bollag; Conrad Guo; Angel Rubio; Richard Near; Wenda Gao; Sreekar Challa; Vennela Chukka; Jeffrey Gao; Avery Kelly; Tamar Landesman; Tyler VanHelene; Xuemei Zhong
Journal:  Front Immunol       Date:  2021-09-23       Impact factor: 7.561

Review 6.  Current Understanding of Natural Antibodies and Exploring the Possibilities of Modulation Using Veterinary Models. A Review.

Authors:  G IJsbrand Reyneveld; Huub F J Savelkoul; Henk K Parmentier
Journal:  Front Immunol       Date:  2020-09-10       Impact factor: 7.561

  6 in total

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