BACKGROUND: The association of allergic diseases, drug adverse reactions and elevated total immunoglobulin E (IgE) concentration in systemic lupus erythematosus patients remains controversial. The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosus patients, and in the control group as well. METHODS: Total IgE concentration was evaluated by enzyme-linked immunosorbent assay. RESULTS AND CONCLUSIONS: The results of our study revealed that concomitant allergic diseases were not more frequent in systemic lupus erythematosus patients than in the general population. Total IgE concentration was significantly higher during the active stage of the disease. Drug reactions were very frequent but not connected with IgE elevation. Our results indicate that IgE may play a role in lupus pathogenesis, especially in the active phase of the disease.
BACKGROUND: The association of allergic diseases, drug adverse reactions and elevated total immunoglobulin E (IgE) concentration in systemic lupus erythematosuspatients remains controversial. The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosuspatients, and in the control group as well. METHODS: Total IgE concentration was evaluated by enzyme-linked immunosorbent assay. RESULTS AND CONCLUSIONS: The results of our study revealed that concomitant allergic diseases were not more frequent in systemic lupus erythematosuspatients than in the general population. Total IgE concentration was significantly higher during the active stage of the disease. Drug reactions were very frequent but not connected with IgE elevation. Our results indicate that IgE may play a role in lupus pathogenesis, especially in the active phase of the disease.
Authors: E M Tan; A S Cohen; J F Fries; A T Masi; D J McShane; N F Rothfield; J G Schaller; N Talal; R J Winchester Journal: Arthritis Rheum Date: 1982-11
Authors: Yu-Ping Hsiao; Jeng-Dau Tsai; Chih-Hsin Muo; Chung-Hung Tsai; Fung-Chang Sung; Ya-Tang Liao; Yen-Jung Chang; Jen-Hung Yang Journal: Int J Environ Res Public Health Date: 2014-08-08 Impact factor: 3.390
Authors: Jill Henault; Jeffrey M Riggs; Jodi L Karnell; Vladimir M Liarski; Jianqing Li; Lena Shirinian; Linda Xu; Kerry A Casey; Michael A Smith; Deepak B Khatry; Liat Izhak; Lorraine Clarke; Ronald Herbst; Rachel Ettinger; Michelle Petri; Marcus R Clark; Tomas Mustelin; Roland Kolbeck; Miguel A Sanjuan Journal: Nat Immunol Date: 2015-12-21 Impact factor: 25.606