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Literature DB >> 12774844

Morphofunctional changes in the pineal gland during dynamic adaptation to hypothermia.

Abstract

The effects of stress induced by hypothermia (+4 degrees C for 3 h) on the pathways of serotonin metabolism in the pineal gland and on its structure were studied in adult male Wistar rats. These experiments showed that the melatonin-forming function of the epiphysis undergoes phasic changes during adaptation: there was a significant increase during the first 15 min, which was followed by gradual inhibition (to initial by 30 min) and then sharp suppression (at 3 h). Suppression of the functional activity of the pineal gland occurred because of exclusion of a proportion of pinealocytes from the process of active functioning.

Entities: Chemical Disease Species

Mesh：

Substances：
Serotonin
Melatonin

Year: 2003 PMID： 12774844 DOI： 10.1023/a:1022859910477

Source DB: PubMed Journal: Neurosci Behav Physiol ISSN： 0097-0549

15 in total

1. The pathophysiological mechanisms of the onset of death through accidental hypothermia and the presentation of "The little match girl" case.

Authors: Ionuţ Isaia Jeican
Journal: Clujul Med Date: 2014-01-30

1 in total

Morphofunctional changes in the pineal gland during dynamic adaptation to hypothermia.

1. Rat pinealocyte reactive response to a long-term stress inducement.

2. Fluorometric determination of indole derivatives.

Review 3. The oxidant/antioxidant network: role of melatonin.

4. N-acetylserotonin is a better extra- and intracellular antioxidant than melatonin.

5. [The participation of brain noradrenergic structures in thermoregulation during cold adaptation].

Review 6. Homeostatic versus circadian effects of melatonin on core body temperature in humans.

Review 7. Heat shock proteins as cellular lifeguards.

8. Responses to cold, heat, and pain increase locomotion in rats and are attenuated by pinealectomy.

9. Scavenging of reactive oxygen species by melatonin.

10. Effects of cold exposure or TRH on the serum TSH levels in the iron-deficient rat.

1. The pathophysiological mechanisms of the onset of death through accidental hypothermia and the presentation of "The little match girl" case.