BACKGROUND AND AIMS: This study assessed the efficacy and safety of irinotecan (CPT-11) in the treatment of patients with unresectable esophageal carcinoma. PATIENTS AND METHODS: Ten patients with esophageal squamous cell carcinoma (SCC) and three with adenocarcinoma (AC) were treated with CPT-11. Eight of the 13 patients were pretreated by surgery, radio-, or chemotherapy. CPT-11 was administered in repeated 6-week cycles consisting of CPT-11 once weekly for 4 weeks, followed by a 2-week rest. The starting dose of CPT-11 was 125 mg/m(2) given intravenously over 60 min; subsequent doses were adjusted based on tolerance and toxicity. Nine patients were evaluable for response. RESULTS: Two patients showed a partial response (one SCC, one AC) and two others disease stabilization (one SCC, one AC). The mean time to progression was 3.8 months. Mean survival since study entry was 6.1 months. In the 103 administrations we observed grade 3 or 4 toxicity on six occasions with diarrhea, five with neutropenia, and one with nausea and vomiting. Toxicity required dose reductions in five patients; in two of these patients treatment was stopped because of severe toxicity. No treatment related deaths occurred. CONCLUSION: CPT-11 as single-agent therapy is modestly effective against squamous cell cancer of the esophagus.
BACKGROUND AND AIMS: This study assessed the efficacy and safety of irinotecan (CPT-11) in the treatment of patients with unresectable esophageal carcinoma. PATIENTS AND METHODS: Ten patients with esophageal squamous cell carcinoma (SCC) and three with adenocarcinoma (AC) were treated with CPT-11. Eight of the 13 patients were pretreated by surgery, radio-, or chemotherapy. CPT-11 was administered in repeated 6-week cycles consisting of CPT-11 once weekly for 4 weeks, followed by a 2-week rest. The starting dose of CPT-11 was 125 mg/m(2) given intravenously over 60 min; subsequent doses were adjusted based on tolerance and toxicity. Nine patients were evaluable for response. RESULTS: Two patients showed a partial response (one SCC, one AC) and two others disease stabilization (one SCC, one AC). The mean time to progression was 3.8 months. Mean survival since study entry was 6.1 months. In the 103 administrations we observed grade 3 or 4 toxicity on six occasions with diarrhea, five with neutropenia, and one with nausea and vomiting. Toxicity required dose reductions in five patients; in two of these patients treatment was stopped because of severe toxicity. No treatment related deaths occurred. CONCLUSION:CPT-11 as single-agent therapy is modestly effective against squamous cell cancer of the esophagus.
Authors: C F Verschraegen; T Levy; A P Kudelka; E Llerena; K Ende; R S Freedman; C L Edwards; M Hord; M Steger; A L Kaplan; D Kieback; A Fishman; J J Kavanagh Journal: J Clin Oncol Date: 1997-02 Impact factor: 44.544
Authors: Jaffer A Ajani; Jackie Baker; Peter W T Pisters; Linus Ho; Paul F Mansfield; Barry W Feig; Chusilp Charnsangavej Journal: Cancer Date: 2002-02-01 Impact factor: 6.860
Authors: J A Conti; N E Kemeny; L B Saltz; Y Huang; W P Tong; T C Chou; M Sun; S Pulliam; C Gonzalez Journal: J Clin Oncol Date: 1996-03 Impact factor: 44.544
Authors: D Bareiss; R Stabenow; R Müller; B Eisinger; C Stegmaier; P Däubler; M Zeitz; H Scherübl Journal: Dtsch Med Wochenschr Date: 2002-06-21 Impact factor: 0.628
Authors: Ming Bai; Meng Wang; Ting Deng; Yuxian Bai; Kai Zang; Zhanhui Miao; Wenlin Gai; Liangzhi Xie; Yi Ba Journal: Cancer Biol Med Date: 2022-01-12 Impact factor: 4.248