Literature DB >> 1277417

Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium.

G A Klassen, F Sestier, A L'Abbate, R R Mildenberger, D T Zborowska-Sluis.   

Abstract

Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.

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Year:  1976        PMID: 1277417     DOI: 10.1161/01.cir.54.1.14

Source DB:  PubMed          Journal:  Circulation        ISSN: 0009-7322            Impact factor:   29.690


  1 in total

1.  Supression of ventricular extrasystoles by perhexiline.

Authors:  T G Pickering; L Goulding
Journal:  Br Heart J       Date:  1978-08
  1 in total

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