Literature DB >> 12773143

Electron transfer in human cytochrome P450 reductase.

A Gutierrez1, A Grunau, M Paine, A W Munro, C R Wolf, G C K Roberts, N S Scrutton.   

Abstract

Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.

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Year:  2003        PMID： 12773143     DOI： 10.1042/bst0310497

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  16 in total

1.  Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions.

Authors:  Vladimir Mishin; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Journal:  Toxicol Sci       Date:  2014-07-24       Impact factor: 4.849

2.  Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.

Authors:  Mohammad M Haque; Mekki Bayachou; Jesus Tejero; Claire T Kenney; Naw M Pearl; Sang-Choul Im; Lucy Waskell; Dennis J Stuehr
Journal:  FEBS J       Date:  2014-10-25       Impact factor: 5.542

3.  Effects of genetic factors on the pharmacokinetics and pharmacodynamics of amlodipine in primary hypertensive patients.

Authors:  Chengxian Guo; Q I Pei; Hongyi Tan; Zhijun Huang; Hong Yuan; Guoping Yang
Journal:  Biomed Rep       Date:  2014-12-02

4.  A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.

Authors:  Mohammad M Haque; Claire Kenney; Jesús Tejero; Dennis J Stuehr
Journal:  FEBS J       Date:  2011-09-15       Impact factor: 5.542

5.  Associations of cytochrome P450 oxidoreductase genetic polymorphisms with smoking cessation in a Chinese population.

Authors:  Huijie Li; Suyun Li; Qiang Wang; Chongqi Jia
Journal:  Hum Genet       Date:  2016-09-22       Impact factor: 4.132

6.  Comparing the electronic properties and docking calculations of heme derivatives on CYP2B4.

Authors:  Jessica E Mendieta-Wejebe; Martha C Rosales-Hernández; Hulme Rios; José Trujillo-Ferrara; Gilberto López-Pérez; Feliciano Tamay-Cach; Rafael Ramos-Morales; José Correa-Basurto
Journal:  J Mol Model       Date:  2008-05-14       Impact factor: 1.810

Review 7.  NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.

Authors:  Takashi Iyanagi; Chuanwu Xia; Jung-Ja P Kim
Journal:  Arch Biochem Biophys       Date:  2012-09-11       Impact factor: 4.013

8.  Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.

Authors:  Robielyn P Ilagan; Mauro Tiso; David W Konas; Craig Hemann; Deborah Durra; Russ Hille; Dennis J Stuehr
Journal:  J Biol Chem       Date:  2008-05-16       Impact factor: 5.157

Review 9.  Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.

Authors:  Dennis J Stuehr; Jesús Tejero; Mohammad M Haque
Journal:  FEBS J       Date:  2009-07-03       Impact factor: 5.542

10.  Dissecting the kinetics of the NADP(+)-FADH2 charge transfer complex and flavin semiquinones in neuronal nitric oxide synthase.

Authors:  Huiying Li; Joumana Jamal; Georges Chreifi; Vikram Venkatesh; Hoda Abou-Ziab; Thomas L Poulos
Journal:  J Inorg Biochem       Date:  2013-03-22       Impact factor: 4.155
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