OBJECTIVE: The hub connecting the catheter and the infusion equipment is a common portal of entry for bacteria causing catheter-related sepsis. We assessed the efficacy of a new hub model (Segur-Lock) that incorporates an antiseptic chamber filled with 3% iodinated alcohol in preventing endoluminal catheter contamination and catheter-related bloodstream infection arising at the hub. DESIGN: Prospective, randomized, multicenter study. SETTING:Seven medical and surgical adult intensive care units in Spain. PATIENTS: A total of 230 patients aged 18 yrs or older requiring the insertion of a nontunneled central venous catheter for >or=6 days from January 1, 1998, to April 30, 1999. INTERVENTIONS: Patients were randomized at the time of catheter insertion to receive catheters with standard Luer-lock connector (control group, n = 114) or catheters with the new hub model (n = 116). MEASUREMENTS AND MAIN RESULTS: Skin, catheter tip, and hub cultures were performed at the time the catheter was withdrawn because therapy was terminated or due to suspicion of sepsis, in which case peripheral blood and infusate cultures were simultaneously taken. Catheter-related bloodstream infection was diagnosed in 19 (8.3%) patients. Catheters were more often withdrawn because of suspicion of infection in the control group (43.8%) than in the new hub model group (30.1%, p <.035). The prevalence of culture-positive catheter hubs without associated bacteremia (colonization) was higher in the control group (14.4% vs. 4.3%, p <.001). Catheter-related bloodstream infection from the catheter hub also occurred more frequently in controls than in patients assigned to the new hub model (7% vs. 1.7%; p <.049; relative risk, 4.14; 95% confidence interval, 0.8-19). CONCLUSIONS: This new antiseptic chamber-containing hub has proved to be effective in preventing endoluminal bacterial colonization and catheter-related bloodstream infection from hub contamination in intensive care unit patients with central venous catheters inserted for >or=6 days.
RCT Entities:
OBJECTIVE: The hub connecting the catheter and the infusion equipment is a common portal of entry for bacteria causing catheter-related sepsis. We assessed the efficacy of a new hub model (Segur-Lock) that incorporates an antiseptic chamber filled with 3% iodinated alcohol in preventing endoluminal catheter contamination and catheter-related bloodstream infection arising at the hub. DESIGN: Prospective, randomized, multicenter study. SETTING: Seven medical and surgical adult intensive care units in Spain. PATIENTS: A total of 230 patients aged 18 yrs or older requiring the insertion of a nontunneled central venous catheter for >or=6 days from January 1, 1998, to April 30, 1999. INTERVENTIONS:Patients were randomized at the time of catheter insertion to receive catheters with standard Luer-lock connector (control group, n = 114) or catheters with the new hub model (n = 116). MEASUREMENTS AND MAIN RESULTS: Skin, catheter tip, and hub cultures were performed at the time the catheter was withdrawn because therapy was terminated or due to suspicion of sepsis, in which case peripheral blood and infusate cultures were simultaneously taken. Catheter-related bloodstream infection was diagnosed in 19 (8.3%) patients. Catheters were more often withdrawn because of suspicion of infection in the control group (43.8%) than in the new hub model group (30.1%, p <.035). The prevalence of culture-positive catheter hubs without associated bacteremia (colonization) was higher in the control group (14.4% vs. 4.3%, p <.001). Catheter-related bloodstream infection from the catheter hub also occurred more frequently in controls than in patients assigned to the new hub model (7% vs. 1.7%; p <.049; relative risk, 4.14; 95% confidence interval, 0.8-19). CONCLUSIONS: This new antiseptic chamber-containing hub has proved to be effective in preventing endoluminal bacterial colonization and catheter-related bloodstream infection from hub contamination in intensive care unit patients with central venous catheters inserted for >or=6 days.
Authors: L Lorente; A Jiménez; M M Martín; J Castedo; R Galván; C García; M T Brouard; M L Mora Journal: Eur J Clin Microbiol Infect Dis Date: 2009-04-16 Impact factor: 3.267
Authors: L Lorente; A Jiménez; C García; R Galván; J Castedo; M M Martín; M L Mora Journal: Eur J Clin Microbiol Infect Dis Date: 2008-04-02 Impact factor: 3.267
Authors: M Angeles García-Teresa; Juan Casado-Flores; M Angel Delgado Domínguez; Jorge Roqueta-Mas; Francisco Cambra-Lasaosa; Andrés Concha-Torre; Cristina Fernández-Pérez Journal: Intensive Care Med Date: 2007-01-19 Impact factor: 17.440
Authors: Cristóbal León; Sergio Ruiz-Santana; Jordi Rello; Maria V de la Torre; Jordi Vallés; Francisco Alvarez-Lerma; Rafael Sierra; Pedro Saavedra; Francisco Alvarez-Salgado Journal: Intensive Care Med Date: 2004-07-20 Impact factor: 17.440
Authors: Bart J Rijnders; Willy E Peetermans; Charles Verwaest; Alexander Wilmer; Eric Van Wijngaerden Journal: Intensive Care Med Date: 2004-03-04 Impact factor: 17.440