| Literature DB >> 12771413 |
Orlando de Jesus1, Paul R Smith1, Lindsay C Spender1, Claudio Elgueta Karstegl1, Hans Helmut Niller2, Dolly Huang3, Paul J Farrell1.
Abstract
Two sequences required for activity of the Epstein-Barr virus BART RNA promoter in transfection assays have been identified by site-directed mutagenesis. One contains a consensus AP-1 site; the other has some similarity to Ets and Stat consensus binding sites. Candidate sequences were suggested by mapping a region of unmethylated DNA in EBV around the BART promoter followed by in vivo footprinting the promoter in the C666-1 nasopharyngeal carcinoma cell line, which expresses BART RNAs. The data are presented in the context of a revised EBV DNA sequence, known as EBV wt, that is proposed as a future standard sequence for EBV.Entities:
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Year: 2003 PMID： 12771413 DOI： 10.1099/vir.0.19054-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891