BACKGROUND: In chronic renal failure patients, the parathyroid glands progress from diffuse hyperplasia to nodular hyperplasia, and it is important to distinguish between these as the latter form is more aggressive. This progress can be confirmed histologically, but the present study aimed to determine whether the different types of hyperplasia could be distinguished by power-Doppler ultrasonography (US). METHODS: Twenty-one consecutive renal failure patients were scheduled to undergo parathyroidectomy (PTx). Of 70 resected parathyroid glands, 63 were assessed by pre-operative power-Doppler US, classified into four groups based on the flow signal pattern and then correlated with the post-operative histopathology. RESULTS: With power-Doppler US imaging, 60.0% of glands without a signal inside the gland were diagnosed as diffuse hyperplasia or diffuse hyperplasia with early nodularity. Of glands with in-gland signals, 83.7% were nodular or had a single nodule typical of nodular hyperplasia. Even when the focus was on parathyroid glands weighing <or=0.5 g, similar results were obtained. CONCLUSIONS: Power-Doppler US imaging is a useful method for determining the pathological features of parathyroid glands and is recommended for selecting the most suitable therapy.
BACKGROUND: In chronic renal failurepatients, the parathyroid glands progress from diffuse hyperplasia to nodular hyperplasia, and it is important to distinguish between these as the latter form is more aggressive. This progress can be confirmed histologically, but the present study aimed to determine whether the different types of hyperplasia could be distinguished by power-Doppler ultrasonography (US). METHODS: Twenty-one consecutive renal failurepatients were scheduled to undergo parathyroidectomy (PTx). Of 70 resected parathyroid glands, 63 were assessed by pre-operative power-Doppler US, classified into four groups based on the flow signal pattern and then correlated with the post-operative histopathology. RESULTS: With power-Doppler US imaging, 60.0% of glands without a signal inside the gland were diagnosed as diffuse hyperplasia or diffuse hyperplasia with early nodularity. Of glands with in-gland signals, 83.7% were nodular or had a single nodule typical of nodular hyperplasia. Even when the focus was on parathyroid glands weighing <or=0.5 g, similar results were obtained. CONCLUSIONS: Power-Doppler US imaging is a useful method for determining the pathological features of parathyroid glands and is recommended for selecting the most suitable therapy.
Authors: Jill Gwiasda; Alexander Kaltenborn; Jörg A Müller; Michaela Serttas; Georg W F Scheumann; Harald Schrem; Mark D Jäger Journal: Langenbecks Arch Surg Date: 2017-01-04 Impact factor: 3.445
Authors: C Vulpio; M Bossola; S C Magalini; P Silvestri; G Fadda; M Ciliberti; M L D'Andrea; G Maresca Journal: Radiol Med Date: 2012-10-22 Impact factor: 3.469
Authors: Mark D Jäger; Michaela Serttas; Jan Beneke; Jörg A Müller; Harald Schrem; Alexander Kaltenborn; Wolf Ramackers; Bastian P Ringe; Jill Gwiasda; Wolfgang Tränkenschuh; Jürgen Klempnauer; Georg F W Scheumann Journal: PLoS One Date: 2017-10-17 Impact factor: 3.240