BACKGROUND: Autoregulation of blood flow that maintains steady perfusion over the range of systemic blood pressure is compromised by stroke. OBJECTIVES: To determine whether cerebral vasoregulation is impaired in stroke during orthostatic stress. METHODS: Subjects included 30 control subjects, 30 with hypertension, and 20 with minor stroke and were studied using transcranial Doppler. Bilateral blood flow velocities (BFVs) from middle cerebral arteries, heart rate, blood pressure (BP), and CO2 were obtained during hyperventilation and CO2 rebreathing during supine rest and tilt at 80 degrees. Side-to-side BFV difference, vasomotor range (VMR), and cerebrovascular resistance (CVR) were calculated during normo-, hypo-, and hypercapnia. RESULTS: Mean BFVs were similar between groups in supine position but differed during tilt. BFV diminished on the stroke side during tilt with hyperventilation and CO2 rebreathing (p < 0.0001). CVR increased (p < 0.0001) and VMR decreased (p < 0.01) on the stroke side. Vasoregulation was preserved on the normal side. BFV asymmetry differentiated patients with stroke from the other groups (p < 0.0001). BFV difference between the normal vs stroke side was the largest in stroke-normotensive (n = 7) compared with stroke-hypertensive (n = 13) patients and the two other groups (p < 0.0001). BFV asymmetry in stroke was associated with lower orthostatic BP (p < 0.0001). CONCLUSIONS: Cerebral vasoregulation is impaired with minor stroke, and cerebral blood flow depends on blood pressure. Decline of blood flow velocities during orthostatic stress may pose a risk of silent hypoperfusion.
BACKGROUND: Autoregulation of blood flow that maintains steady perfusion over the range of systemic blood pressure is compromised by stroke. OBJECTIVES: To determine whether cerebral vasoregulation is impaired in stroke during orthostatic stress. METHODS: Subjects included 30 control subjects, 30 with hypertension, and 20 with minor stroke and were studied using transcranial Doppler. Bilateral blood flow velocities (BFVs) from middle cerebral arteries, heart rate, blood pressure (BP), and CO2 were obtained during hyperventilation and CO2 rebreathing during supine rest and tilt at 80 degrees. Side-to-side BFV difference, vasomotor range (VMR), and cerebrovascular resistance (CVR) were calculated during normo-, hypo-, and hypercapnia. RESULTS: Mean BFVs were similar between groups in supine position but differed during tilt. BFV diminished on the stroke side during tilt with hyperventilation and CO2 rebreathing (p < 0.0001). CVR increased (p < 0.0001) and VMR decreased (p < 0.01) on the stroke side. Vasoregulation was preserved on the normal side. BFV asymmetry differentiated patients with stroke from the other groups (p < 0.0001). BFV difference between the normal vs stroke side was the largest in stroke-normotensive (n = 7) compared with stroke-hypertensive (n = 13) patients and the two other groups (p < 0.0001). BFV asymmetry in stroke was associated with lower orthostatic BP (p < 0.0001). CONCLUSIONS: Cerebral vasoregulation is impaired with minor stroke, and cerebral blood flow depends on blood pressure. Decline of blood flow velocities during orthostatic stress may pose a risk of silent hypoperfusion.
Authors: Michael L Alosco; John Gunstad; Xiaomeng Xu; Uraina S Clark; Donald R Labbe; Hannah H Riskin-Jones; Gretel Terrero; Nicolette F Schwarz; Edward G Walsh; Athena Poppas; Ronald A Cohen; Lawrence H Sweet Journal: J Am Soc Hypertens Date: 2014-04-13
Authors: Vera Novak; Kun Hu; Laura Desrochers; Peter Novak; Louis Caplan; Lewis Lipsitz; Magdy Selim Journal: Stroke Date: 2009-12-03 Impact factor: 7.914
Authors: Wenjing Wei; Helmet T Karim; Chemin Lin; Akiko Mizuno; Carmen Andreescu; Jordan F Karp; Charles F Reynolds; Howard J Aizenstein Journal: J Clin Psychiatry Date: 2018-10-23 Impact factor: 4.384