Literature DB >> 12767601

Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.

Maria Teresa Cocco1, Cenzo Congiu, Valentina Onnis, Micaela Morelli, Omar Cauli.   

Abstract

A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

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Year:  2003        PMID： 12767601     DOI： 10.1016/s0223-5234(03)00074-6

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  14 in total

Review 1.  The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

Authors:  C J Fowler; P S Naidu; A Lichtman; V Onnis
Journal:  Br J Pharmacol       Date:  2009-02       Impact factor: 8.739

2.  Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model.

Authors:  Susana Paula Moreira Fischer; Indiara Brusco; Camila Camponogara; Mariana Piana; Henrique Faccin; Luciana Assis Gobo; Leandro Machado de Carvalho; Sara Marchesan Oliveira
Journal:  Inflammopharmacology       Date:  2017-08-11       Impact factor: 4.473

Review 3.  A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.

Authors:  Rita Scarpelli; Oscar Sasso; Daniele Piomelli
Journal:  ChemMedChem       Date:  2015-10-21       Impact factor: 3.466

4.  Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.

Authors:  Christopher J Fowler; Emmelie Björklund; Aron H Lichtman; Pattipati S Naidu; Cenzo Congiu; Valentina Onnis
Journal:  J Enzyme Inhib Med Chem       Date:  2012-01-06       Impact factor: 5.051

5.  Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.

Authors:  Tyler M Rose; Christopher A Reilly; Cassandra E Deering-Rice; Clinton Brewster; Chelsea Brewster
Journal:  Bioorg Med Chem Lett       Date:  2014-10-28       Impact factor: 2.823

Review 6.  Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.

Authors:  May Hamza; Raymond A Dionne
Journal:  Curr Mol Pharmacol       Date:  2009-01       Impact factor: 3.339

7.  Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

Authors:  Marco Migliore; Damien Habrant; Oscar Sasso; Clara Albani; Sine Mandrup Bertozzi; Andrea Armirotti; Daniele Piomelli; Rita Scarpelli
Journal:  Eur J Med Chem       Date:  2015-12-23       Impact factor: 6.514

Review 8.  The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action.

Authors:  C J Fowler
Journal:  Br J Pharmacol       Date:  2007-07-09       Impact factor: 8.739

Review 9.  Targeting CB2 receptors and the endocannabinoid system for the treatment of pain.

Authors:  Praveen Anand; Garth Whiteside; Christopher J Fowler; Andrea G Hohmann
Journal:  Brain Res Rev       Date:  2008-12-25

10.  Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

Authors:  Sandra Gouveia-Figueira; Jessica Karlsson; Alessandro Deplano; Sanaz Hashemian; Mona Svensson; Marcus Fredriksson Sundbom; Cenzo Congiu; Valentina Onnis; Christopher J Fowler
Journal:  PLoS One       Date:  2015-09-25       Impact factor: 3.240
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