| Literature DB >> 12767532 |
Tuyoshi Shoji1, Hiroyuki Konno, Tatsuo Tanaka, Takanori Sakaguchi, Kenichi Sunayama, Megumi Baba, Kinji Kamiya, Manabu Ohta, Takeshi Kaneko, Akira Igarashi, Satoshi Nakamura.
Abstract
The aim of the present study is to investigate the relation of cyclooxygenase (COX)-2 with liver metastasis. Pieces of human colon cancer xenograft were implanted orthotopically (CI), as well as intraperitoneally, and subcutaneously. Liver metastasis developed most frequently, and the COX-2 expression of both mRNA and protein of the tumors was the most dominant in the CI group. In contrast, the expression of COX-1 or vascular endothelial cell growth factor mRNAs had no significant differences among the groups. The intensity of COX-2 mRNA was negatively correlated with the apoptotic index. In conclusion, COX-2 plays an important role in organ-specific metastasis of the colon cancer.Entities:
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Year: 2003 PMID： 12767532 DOI： 10.1016/s0304-3835(02)00108-8
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679