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Literature DB >> 12767258

Physiological and pathological roles of Apaf1 and the apoptosome.

Abstract

Different cellular pathways can lead to apoptosis. Apaf1 is the molecular core of the apoptosome, a multiproteic complex mediating the so-called mitochondrial pathway of cell death. The importance of this pathway during development has been clearly demonstrated by knocking out key genes. Also, the relevance of Apaf1 dosage during development has been recently underlined. Moreover, a growing body of evidences seems to point out a possible role of the mitochondria-dependent apoptosis in different pathologies. In particular, we discuss here some recent evidences regarding the putative role of the apoptosome in neurodegeneration and cancer.

Entities: Chemical

Mesh：

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Year: 2003 PMID： 12767258 PMCID： PMC6740308 DOI： 10.1111/j.1582-4934.2003.tb00199.x

Source DB: PubMed Journal: J Cell Mol Med ISSN： 1582-1838 Impact factor: 5.310

89 in total

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4. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

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Journal: J Neurochem Date: 1999-07 Impact factor: 5.372

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Journal: J Biol Chem Date: 1999-07-23 Impact factor: 5.157

7. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

Authors: M S Soengas; R M Alarcón; H Yoshida; A J Giaccia; R Hakem; T W Mak; S W Lowe
Journal: Science Date: 1999-04-02 Impact factor: 47.728

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Authors: K J Ivins; E T Bui; C W Cotman
Journal: Neurobiol Dis Date: 1998-11 Impact factor: 5.996

9. Expression of extended polyglutamine sequentially activates initiator and effector caspases.

Authors: T Miyashita; J Matsui; Y Ohtsuka; U Mami; S Fujishima; Y Okamura-Oho; T Inoue; M Yamada
Journal: Biochem Biophys Res Commun Date: 1999-04-21 Impact factor: 3.575

10. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

Authors: F G Gervais; D Xu; G S Robertson; J P Vaillancourt; Y Zhu; J Huang; A LeBlanc; D Smith; M Rigby; M S Shearman; E E Clarke; H Zheng; L H Van Der Ploeg; S C Ruffolo; N A Thornberry; S Xanthoudakis; R J Zamboni; S Roy; D W Nicholson
Journal: Cell Date: 1999-04-30 Impact factor: 41.582

12 in total

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Authors: Qazi M Ashraf; Om P Mishra; Maria Delivoria-Papadopoulos
Journal: Neurosci Lett Date: 2007-01-14 Impact factor: 3.046

2. Regulation of neuronal P53 activity by CXCR 4.

Authors: Muhammad Z Khan; Saori Shimizu; Jeegar P Patel; Autumn Nelson; My-Thao Le; Anna Mullen-Przeworski; Renato Brandimarti; Alessandro Fatatis; Olimpia Meucci
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Review 3. Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling.

Authors: Peixin Yang; E Albert Reece; Fang Wang; Rinat Gabbay-Benziv
Journal: Am J Obstet Gynecol Date: 2014-11-27 Impact factor: 8.661

4. Structure of an apoptosome-procaspase-9 CARD complex.

Authors: Shujun Yuan; Xinchao Yu; Maya Topf; Steven J Ludtke; Xiaodong Wang; Christopher W Akey
Journal: Structure Date: 2010-05-12 Impact factor: 5.006

5. Expression of apoptosome pathway-related transcripts in non-small cell lung cancer.

Authors: Evzen Krepela; Jan Procházka; Pavel Fiala; Petr Zatloukal; Pavel Selinger
Journal: J Cancer Res Clin Oncol Date: 2005-10-18 Impact factor: 4.553

6. Suppression of the intrinsic apoptosis pathway by synaptic activity.

Authors: Frédéric Léveillé; Sofia Papadia; Michael Fricker; Karen F S Bell; Francesc X Soriano; Marc-André Martel; Clare Puddifoot; Marlen Habel; David J Wyllie; Chrysanthy Ikonomidou; Aviva M Tolkovsky; Giles E Hardingham
Journal: J Neurosci Date: 2010-02-17 Impact factor: 6.167

10. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification.

Authors: Ying Wang; Yang Cao; Qing Zhu; Xianfeng Gu; Yi Zhun Zhu
Journal: Sci Rep Date: 2016-07-22 Impact factor: 4.379