Literature DB >> 12766537

Is mammalian aging genetically controlled?

João Pedro de Magalhães1.   

Abstract

The rate of aging is species-specific, indicating that aging has a strong genetic component. Amongst mammals, the synchronization of the aging process suggests the presence of genetic determinants. In addition, single gene manipulations can change the rate of aging and demonstrate how a few genetic factors can regulate aging. Therefore, I propose that aging is regulated by a small set of genetic mechanisms, a single clock. If we can find what these regulatory mechanisms are, then instead of trying to delay age-related pathologies one by one we may be able to discover how to delay the entire aging process and most, if not all, of its pathologies.

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Year:  2003        PMID: 12766537     DOI: 10.1023/a:1023356005749

Source DB:  PubMed          Journal:  Biogerontology        ISSN: 1389-5729            Impact factor:   4.277


  7 in total

1.  Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging.

Authors:  João Pedro de Magalhães; George M Church
Journal:  Mech Ageing Dev       Date:  2007-03-25       Impact factor: 5.432

2.  A Theory of Socio-economic Disparities in Health over the Life Cycle.

Authors:  Titus J Galama; Hans van Kippersluis
Journal:  Econ J (London)       Date:  2018-05-19

3.  Prediction and characterization of human ageing-related proteins by using machine learning.

Authors:  Csaba Kerepesi; Bálint Daróczy; Ádám Sturm; Tibor Vellai; András Benczúr
Journal:  Sci Rep       Date:  2018-03-06       Impact factor: 4.379

4.  A mesenchymal stromal cell gene signature for donor age.

Authors:  Hugo Alves; Jetty van Ginkel; Nathalie Groen; Marc Hulsman; Anouk Mentink; Marcel Reinders; Clemens van Blitterswijk; Jan de Boer
Journal:  PLoS One       Date:  2012-08-23       Impact factor: 3.240

5.  Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?

Authors:  João Pedro de Magalhães
Journal:  FASEB J       Date:  2012-09-10       Impact factor: 5.191

6.  Aging is not senescence: a short computer demonstration and implications for medical practice.

Authors:  Thiago Oliveira Monaco; Paulo Sergio Panse Silveira
Journal:  Clinics (Sao Paulo)       Date:  2009-05       Impact factor: 2.365

Review 7.  Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.

Authors:  Peter Laun; Carlo V Bruschi; J Richard Dickinson; Mark Rinnerthaler; Gino Heeren; Richard Schwimbersky; Raphaela Rid; Michael Breitenbach
Journal:  Nucleic Acids Res       Date:  2007-11-06       Impact factor: 16.971

  7 in total

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