OBJECTIVE: Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. We prospectively evaluated the association between type 2 diabetes and invasive breast cancer incidence in the Nurses' Health Study. RESEARCH DESIGN AND METHODS: A total of 116,488 female nurses who were 30-55 years old and free of cancer in 1976 were followed through 1996 for the occurrence of type 2 diabetes and through 1998 for incident invasive breast cancer, verified by medical records and pathology reports. RESULTS: During 2.3 million person-years of follow-up, we identified 6,220 women with type 2 diabetes and 5,189 incident cases of invasive breast cancer. Women with type 2 diabetes had a modestly elevated incidence of breast cancer (hazard ratio [HR] = 1.17; 95% CI 1.01-1.35) compared with women without diabetes, independent of age, obesity, family history of breast cancer, history of benign breast disease, reproductive factors, physical activity, and alcohol consumption. This association was apparent among postmenopausal women (1.16; 0.98-1.62) but not premenopausal women (0.83; 0.48-1.42). The association was predominant among women with estrogen receptor-positive breast cancer (1.22; 1.01-1.47). CONCLUSIONS: Women with type 2 diabetes may have a slightly increased risk of breast cancer.
OBJECTIVE:Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. We prospectively evaluated the association between type 2 diabetes and invasive breast cancer incidence in the Nurses' Health Study. RESEARCH DESIGN AND METHODS: A total of 116,488 female nurses who were 30-55 years old and free of cancer in 1976 were followed through 1996 for the occurrence of type 2 diabetes and through 1998 for incident invasive breast cancer, verified by medical records and pathology reports. RESULTS: During 2.3 million person-years of follow-up, we identified 6,220 women with type 2 diabetes and 5,189 incident cases of invasive breast cancer. Women with type 2 diabetes had a modestly elevated incidence of breast cancer (hazard ratio [HR] = 1.17; 95% CI 1.01-1.35) compared with women without diabetes, independent of age, obesity, family history of breast cancer, history of benign breast disease, reproductive factors, physical activity, and alcohol consumption. This association was apparent among postmenopausal women (1.16; 0.98-1.62) but not premenopausal women (0.83; 0.48-1.42). The association was predominant among women with estrogen receptor-positive breast cancer (1.22; 1.01-1.47). CONCLUSIONS:Women with type 2 diabetes may have a slightly increased risk of breast cancer.
Authors: Marni Stott-Miller; Chu Chen; Shu-Chun Chuang; Yuan-Chin Amy Lee; Stefania Boccia; Hermann Brenner; Gabriela Cadoni; Luigino Dal Maso; Carlo La Vecchia; Philip Lazarus; Fabio Levi; Keitaro Matsuo; Hal Morgenstern; Heiko Müller; Joshua Muscat; Andrew F Olshan; Mark P Purdue; Diego Serraino; Thomas L Vaughan; Zuo-Feng Zhang; Paolo Boffetta; Mia Hashibe; Stephen M Schwartz Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-12-05 Impact factor: 4.254
Authors: Gertraud Maskarinec; Simone Jacobs; Song-Yi Park; Christopher A Haiman; Veronica W Setiawan; Lynne R Wilkens; Loïc Le Marchand Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-01-13 Impact factor: 4.254
Authors: Zhiguo Zhao; Wanqing Wen; Kyriaki Michailidou; Manjeet K Bolla; Qin Wang; Ben Zhang; Jirong Long; Xiao-Ou Shu; Marjanka K Schmidt; Roger L Milne; Montserrat García-Closas; Jenny Chang-Claude; Sara Lindstrom; Stig E Bojesen; Habibul Ahsan; Kristiina Aittomäki; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Matthias W Beckmann; Alicia Beeghly-Fadiel; Javier Benitez; Carl Blomqvist; Natalia V Bogdanova; Anne-Lise Børresen-Dale; Judith Brand; Hiltrud Brauch; Hermann Brenner; Barbara Burwinkel; Qiuyin Cai; Graham Casey; Georgia Chenevix-Trench; Fergus J Couch; Angela Cox; Simon S Cross; Kamila Czene; Thilo Dörk; Martine Dumont; Peter A Fasching; Jonine Figueroa; Dieter Flesch-Janys; Olivia Fletcher; Henrik Flyger; Florentia Fostira; Marilie Gammon; Graham G Giles; Pascal Guénel; Christopher A Haiman; Ute Hamann; Patricia Harrington; Mikael Hartman; Maartje J Hooning; John L Hopper; Anna Jakubowska; Farzana Jasmine; Esther M John; Nichola Johnson; Maria Kabisch; Sofia Khan; Muhammad Kibriya; Julia A Knight; Veli-Matti Kosma; Mieke Kriege; Vessela Kristensen; Loic Le Marchand; Eunjung Lee; Jingmei Li; Annika Lindblom; Artitaya Lophatananon; Robert Luben; Jan Lubinski; Kathleen E Malone; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Frederik Marme; Catriona McLean; Hanne Meijers-Heijboer; Alfons Meindl; Hui Miao; Kenneth Muir; Susan L Neuhausen; Heli Nevanlinna; Patrick Neven; Janet E Olson; Barbara Perkins; Paolo Peterlongo; Kelly-Anne Phillips; Katri Pylkäs; Anja Rudolph; Regina Santella; Elinor J Sawyer; Rita K Schmutzler; Minouk Schoemaker; Mitul Shah; Martha Shrubsole; Melissa C Southey; Anthony J Swerdlow; Amanda E Toland; Ian Tomlinson; Diana Torres; Thérèse Truong; Giske Ursin; Rob B Van Der Luijt; Senno Verhoef; Shan Wang-Gohrke; Alice S Whittemore; Robert Winqvist; M Pilar Zamora; Hui Zhao; Alison M Dunning; Jacques Simard; Per Hall; Peter Kraft; Paul Pharoah; David Hunter; Douglas F Easton; Wei Zheng Journal: Cancer Causes Control Date: 2016-04-06 Impact factor: 2.506