OBJECTIVE: To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients. DESIGN: Randomized prospective study. SETTING:Zeynep Kamil Hospital IVF Center. PATIENTS: Thirty-two female PCOS patients with clomiphene citrate resistance. INTERVENTIONS: Test group A received 2x850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B. MAIN OUTCOME MEASURES: Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with >or=16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate. RESULTS: The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group. CONCLUSIONS:Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.
RCT Entities:
OBJECTIVE: To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOSpatients. DESIGN: Randomized prospective study. SETTING: Zeynep Kamil Hospital IVF Center. PATIENTS: Thirty-two female PCOSpatients with clomiphene citrate resistance. INTERVENTIONS: Test group A received 2x850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B. MAIN OUTCOME MEASURES: Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with >or=16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate. RESULTS: The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group. CONCLUSIONS:Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.
Authors: Leopoldo O Tso; Michael F Costello; Luiz Eduardo T Albuquerque; Régis B Andriolo; Cristiane R Macedo Journal: Cochrane Database Syst Rev Date: 2014-11-18
Authors: Esmée M Bordewijk; Marleen Nahuis; Michael F Costello; Fulco Van der Veen; Leopoldo O Tso; Ben Willem J Mol; Madelon van Wely Journal: Cochrane Database Syst Rev Date: 2017-01-24
Authors: Leopoldo O Tso; Michael F Costello; Luiz Eduardo T Albuquerque; Regis B Andriolo; Cristiane R Macedo Journal: Cochrane Database Syst Rev Date: 2020-12-21