OBJECTIVE: Human immunodeficiency virus (HIV)-infected women are at risk for cervical intraepithelial neoplasia (CIN) and cancer due to impaired immunosurveillance over human papillomavirus (HPV) infection. Life stress has been implicated in immune decrements in HIV-infected individuals and therefore may contribute to CIN progression over time. The purpose of this study was to determine whether life stress was associated with progression and/or persistence of squamous intraepithelial lesions (SIL), the cytologic diagnosis conferred by Papanicolaou smear, after 1-year follow-up among women co-infected with HIV and HPV. METHOD: Thirty-two HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw, colposcopy, and HPV cervical swab at study entry. Using medical chart review, we then abstracted SIL diagnoses at study entry and after 1-year follow-up. RESULTS: Hierarchical logistic regression analysis revealed that higher life stress increased the odds of developing progressive/persistent SIL over 1 year by approximately seven-fold after covarying relevant biological and behavioral control variables. CONCLUSIONS: These findings suggest that life stress may constitute an independent risk factor for SIL progression and/or persistence in HIV-infected women. Stress management interventions may decrease risk for SIL progression/persistence in women living with HIV.
OBJECTIVE: Human immunodeficiency virus (HIV)-infectedwomen are at risk for cervical intraepithelial neoplasia (CIN) and cancer due to impaired immunosurveillance over human papillomavirus (HPV) infection. Life stress has been implicated in immune decrements in HIV-infected individuals and therefore may contribute to CIN progression over time. The purpose of this study was to determine whether life stress was associated with progression and/or persistence of squamous intraepithelial lesions (SIL), the cytologic diagnosis conferred by Papanicolaou smear, after 1-year follow-up among women co-infected with HIV and HPV. METHOD: Thirty-two HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw, colposcopy, and HPV cervical swab at study entry. Using medical chart review, we then abstracted SIL diagnoses at study entry and after 1-year follow-up. RESULTS: Hierarchical logistic regression analysis revealed that higher life stress increased the odds of developing progressive/persistent SIL over 1 year by approximately seven-fold after covarying relevant biological and behavioral control variables. CONCLUSIONS: These findings suggest that life stress may constitute an independent risk factor for SIL progression and/or persistence in HIV-infectedwomen. Stress management interventions may decrease risk for SIL progression/persistence in women living with HIV.
Authors: Michael H Antoni; Deidre B Pereira; Ilona Marion; Nicole Ennis; Michele Peake Andrasik; Rachel Rose; Judith McCalla; Trudi Simon; Mary Ann Fletcher; Joseph Lucci; Jonell Efantis-Potter; Mary Jo O'Sullivan Journal: J Psychosom Res Date: 2008-10 Impact factor: 3.006
Authors: L Stewart Massad; Denis Agniel; Howard Minkoff; D Heather Watts; Gypsyamber D'Souza; Alexandra M Levine; Teresa M Darragh; Mary Young; Anthony Cajigas; Kathleen Weber Journal: J Low Genit Tract Dis Date: 2011-01 Impact factor: 1.925
Authors: Carolyn Y Fang; Suzanne M Miller; Dana H Bovbjerg; Cynthia Bergman; Mitchell I Edelson; Norman G Rosenblum; Betsy A Bove; Andrew K Godwin; Donald E Campbell; Steven D Douglas Journal: Ann Behav Med Date: 2008-02-13
Authors: Michael H Antoni; Susan K Lutgendorf; Steven W Cole; Firdaus S Dhabhar; Sandra E Sephton; Paige Green McDonald; Michael Stefanek; Anil K Sood Journal: Nat Rev Cancer Date: 2006-03 Impact factor: 60.716
Authors: Stacy M Dodd; Deidre B Pereira; Ilona Marion; Michele Andrasik; Rachel Rose; Trudi Simon; Mary Ann Fletcher; Joseph Lucci; Kevin Maher; Mary Jo O'Sullivan; JoNell Efantis-Potter; Michael H Antoni Journal: Int J Behav Med Date: 2009-05-08