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Literature DB >> 12763023

The fate of the prion protein in the prion/plasminogen complex.

Jack A Kornblatt¹, Stephane Marchal, Human Rezaei, M Judith Kornblatt, Claude Balny, Reinhard Lange, Marie-Pascale Debey, Gaston Hui Bon Hoa, Michael C Marden, Jeanne Grosclaude.

Abstract

The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.

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Year: 2003 PMID： 12763023 DOI： 10.1016/s0006-291x(03)00804-0

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

13 in total

1. The epididymal soluble prion protein forms a high-molecular-mass complex in association with hydrophobic proteins.

Authors: Heath Ecroyd; Maya Belghazi; Jean-Louis Dacheux; Jean-Luc Gatti
Journal: Biochem J Date: 2005-11-15 Impact factor: 3.857

2. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.

Authors: Kwang Soo Kim; Yu Ree Choi; Ji-Young Park; Jung-Ho Lee; Dong Kyu Kim; Seung-Jae Lee; Seung R Paik; Ilo Jou; Sang Myun Park
Journal: J Biol Chem Date: 2012-05-22 Impact factor: 5.157

3. Reduction of canine plasminogen leads to an expanded molecule which precipitates.

Authors: Jack A Kornblatt
Journal: PLoS One Date: 2009-07-10 Impact factor: 3.240

4. Canine plasminogen: spectral responses to changes in 6-aminohexanoate and temperature.

Authors: Jack A Kornblatt; Tanya A Barretto; Ketevan Chigogidze; Bahati Chirwa
Journal: Anal Chem Insights Date: 2007-03-22

Review 5. Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease.

Authors: Sang Myun Park; Kwang Soo Kim
Journal: Prion Date: 2012-11-15 Impact factor: 3.931

6. Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions.

Authors: Younghwan Kim; Jihyun Song; Charles E Mays; William Titlow; Donghoon Yoon; Chongsuk Ryou
Journal: Mol Cell Biochem Date: 2009-03-26 Impact factor: 3.396

The fate of the prion protein in the prion/plasminogen complex.

1. The epididymal soluble prion protein forms a high-molecular-mass complex in association with hydrophobic proteins.

2. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.

3. Reduction of canine plasminogen leads to an expanded molecule which precipitates.

4. Canine plasminogen: spectral responses to changes in 6-aminohexanoate and temperature.

Review 5. Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease.

6. Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions.

Review 7. α-Cleavage of cellular prion protein.

8. Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.

Review 9. Cellular and Molecular Mechanisms of Prion Disease.

10. A novel real-time ultrasonic method for prion protein detection using plasminogen as a capture molecule.