Literature DB >> 12761661

Design of copper DNA intercalators with leishmanicidal activity.

Maribel Navarro1, Efrén José Cisneros-Fajardo, Aníbal Sierralta, Mercedes Fernández-Mestre, Pedro Silva, Dwight Arrieche, Edgar Marchán.   

Abstract

The complexes [Cu(dppz)(NO(3))]NO(3) (1), [Cu(dppz)(2)(NO(3))]NO(3) (2), [Cu(dpq)(NO(3))]NO(3) (3), and [Cu(dpq)(2)(NO(3))]NO(3) (4) were synthesized and characterized by elemental analysis, FAB-mass spectrometry, EPR, UV, and IR spectroscopies, and molar conductivity. DNA interaction studies showed that intercalation is an important way of interacting with DNA for these complexes. The biological activity of these copper complexes was evaluated on Leishmania braziliensis promastigotes, and the results showed leishmanicidal activity. Preliminary ultrastructural studies with the most active complex (2) at 1 h revealed parasite swelling and binucleated cells. This finding suggests that the leishmanicidal activity of the copper complexes could be associated with their interaction with the parasitic DNA.

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Year:  2003        PMID： 12761661     DOI： 10.1007/s00775-002-0427-2

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  12 in total

1.  Recognition and reaction of metallointercalators with DNA.

Authors:  K E Erkkila; D T Odom; J K Barton
Journal:  Chem Rev       Date:  1999-09-08       Impact factor: 60.622

2.  Toward a novel metal-based chemotherapy against tropical diseases. 6. Synthesis and characterization of new copper(II) and gold(I) clotrimazole and ketoconazole complexes and evaluation of their activity against Trypanosoma cruzi.

Authors:  M Navarro; E J Cisneros-Fajardo; T Lehmann; R A Sánchez-Delgado; R Atencio; P Silva; R Lira; J A Urbina
Journal:  Inorg Chem       Date:  2001-12-31       Impact factor: 5.165

3.  In vitro sensitivity of Leishmania donovani to organometallic derivatives of pentamidine.

Authors:  N Mbongo; P M Loiseau; F Lawrence; C Bories; D G Craciunescu; M Robert-Gero
Journal:  Parasitol Res       Date:  1997       Impact factor: 2.289

4.  Trypanocidal and antitumour activity of platinum-metal and platinum-metal-drug dual-function complexes.

Authors:  N P Farrell; J Williamson; D J McLaren
Journal:  Biochem Pharmacol       Date:  1984-04-01       Impact factor: 5.858

5.  The design of new molecular "light switches" for DNA.

Authors:  X H Zou; B H Ye; H Li; Q L Zhang; H Chao; J G Liu; L N Ji; X Y Li
Journal:  J Biol Inorg Chem       Date:  2001-02       Impact factor: 3.358

6.  DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides.

Authors:  L C Perrin; P D Prenzler; C Cullinane; D R Phillips; W A Denny; W D McFadyen
Journal:  J Inorg Biochem       Date:  2000-07-15       Impact factor: 4.155

7.  Neither delta- nor lambda-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation.

Authors:  S Satyanarayana; J C Dabrowiak; J B Chaires
Journal:  Biochemistry       Date:  1992-10-06       Impact factor: 3.162

8.  Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA.

Authors:  A Wolfe; G H Shimer; T Meehan
Journal:  Biochemistry       Date:  1987-10-06       Impact factor: 3.162

9.  Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acid.

Authors:  J B Chaires; N Dattagupta; D M Crothers
Journal:  Biochemistry       Date:  1982-08-17       Impact factor: 3.162

10.  Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.

Authors:  M S Wysor; L A Zwelling; J E Sanders; M M Grenan
Journal:  Science       Date:  1982-07-30       Impact factor: 47.728
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  9 in total

1.  Study of DNA light switch Ru(II) complexes: synthesis, characterization, photocleavage and antimicrobial activity.

Authors:  Praveen Kumar Yata; M Shilpa; P Nagababu; M Rajender Reddy; Laxma Reddy Kotha; Nazar Md Gabra; S Satyanarayana
Journal:  J Fluoresc       Date:  2011-12-23       Impact factor: 2.217

2.  A Study on Spectro-Analytical Aspects, DNA - Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 - (1 - (6 - methoxybenzo [d] thiazol - 2 - ylimino) ethyl) - 6 - methyl - 3H - pyran - 2, 4 - dione and its Metal Complexes.

Authors:  Mudavath Ravi; Kishan Prasad Chennam; B Ushaiah; Ravi Kumar Eslavath; Shyam Perugu; Rajanna Ajumeera; Ch Sarala Devi
Journal:  J Fluoresc       Date:  2015-08-28       Impact factor: 2.217

3.  DNA Binding, Cleavage and Antibacterial Activity of Mononuclear Cu(II), Ni(II) and Co(II) Complexes Derived from Novel Benzothiazole Schiff Bases.

Authors:  Narendrula Vamsikrishna; Marri Pradeep Kumar; Somapangu Tejaswi; Aveli Rambabu
Journal:  J Fluoresc       Date:  2016-05-11       Impact factor: 2.217

4.  Probing the interaction of new and biologically active Pd(II) complex with DNA/BSA via joint experimental and computational studies along with thermodynamic, NLO, FMO and NBO analysis.

Authors:  Ashraf Sadat Dorafshan Tabatabai; Effat Dehghanian; Hassan Mansouri-Torshizi
Journal:  Biometals       Date:  2022-01-17       Impact factor: 2.949

5.  Synthesis, characterization, DNA interactions, DNA cleavage, radical scavenging activity, antibacterial, anti-proliferative and docking studies of new transition metal complexes.

Authors:  Kishan Prasad Chennam; Mudavath Ravi; B Ushaiah; V Srinu; Ravi Kumar Eslavath; Ch Sarala Devi
Journal:  J Fluoresc       Date:  2015-11-06       Impact factor: 2.217

6.  Synthesis, characterization, antioxidant, antileishmanial, anticancer, DNA and theoretical SARS-CoV-2 interaction studies of copper(II) carboxylate complexes.

Authors:  Niaz Muhammad; Ishaq N Khan; Zafar Ali; Mohammad Ibrahim; Shaukat Shujah; Saqib Ali; Muhammad Ikram; Sadia Rehman; Gul Shahzada Khan; Abdul Wadood; Awal Noor; Carola Schulzke
Journal:  J Mol Struct       Date:  2021-12-30       Impact factor: 3.196

7.  Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands.

Authors:  Nahid Shahabadi; Somaye Mohammadi
Journal:  Bioinorg Chem Appl       Date:  2012-08-26       Impact factor: 7.778

8.  Improved antileishmanial activity of Dppz through complexation with antimony(III) and bismuth(III): investigation of the role of the metal.

Authors:  Edgar H Lizarazo-Jaimes; Rubens L Monte-Neto; Priscila G Reis; Nelson G Fernandes; Nivaldo L Speziali; Maria N Melo; Frédéric Frézard; Cynthia Demicheli
Journal:  Molecules       Date:  2012-10-25       Impact factor: 4.411

9.  Zinc(II) Terpyridine Complexes: Substituent Effect on Photoluminescence, Antiproliferative Activity, and DNA Interaction.

Authors:  Jiahe Li; Rongping Liu; Jinzhang Jiang; Xing Liang; Ling Huang; Gang Huang; Hailan Chen; Lixia Pan; Zhen Ma
Journal:  Molecules       Date:  2019-12-10       Impact factor: 4.411
  9 in total

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