Literature DB >> 12761194

The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC.

Hideyuki Mukai1.   

Abstract

PKN is a serine/threonine protein kinase that has a catalytic domain homologous to protein kinase C (PKC) family members and a unique regulatory region containing antiparallel coiled-coil (ACC) domains. PKN is the first identified serine/threonine protein kinase that can bind to and be activated by a small GTPase Rho, and it can also be activated by fatty acids such as arachidonic acid in vitro. PKN is widely distributed in various organisms such as mammal, frog, fly, and starfish. There are at least three different isoforms of PKN (PKNalpha/PAK-1/PRK-1, PKNbeta, and PRK2/PAK-2/PKNgamma) in mammals, each of which shows different enzymological properties, tissue distribution, and varied functions.

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Year:  2003        PMID： 12761194     DOI： 10.1093/jb/mvg019

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  67 in total

1.  PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.

Authors:  Hiroshi Qadota; Takayuki Miyauchi; John F Nahabedian; Jeffrey N Stirman; Hang Lu; Mutsuki Amano; Guy M Benian; Kozo Kaibuchi
Journal:  J Mol Biol       Date:  2011-01-26       Impact factor: 5.469

2.  The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

Authors:  Sean W Wallace; Ana Magalhaes; Alan Hall
Journal:  Mol Cell Biol       Date:  2010-10-25       Impact factor: 4.272

Review 3.  PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.

Authors:  Zhou-shen Zhao; Ed Manser
Journal:  Biochem J       Date:  2005-03-01       Impact factor: 3.857

4.  Genotype-phenotype relationship in three cases with overlapping 19p13.12 microdeletions.

Authors:  Maria C Bonaglia; Susan Marelli; Francesca Novara; Simona Commodaro; Renato Borgatti; Grazia Minardo; Luigi Memo; Elisabeth Mangold; Silvana Beri; Claudio Zucca; Daniele Brambilla; Massimo Molteni; Roberto Giorda; Ruthild G Weber; Orsetta Zuffardi
Journal:  Eur J Hum Genet       Date:  2010-07-21       Impact factor: 4.246

5.  PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury.

Authors:  Qianying Yuan; Chunguang Ren; Wenwen Xu; Björn Petri; Jiasheng Zhang; Yong Zhang; Paul Kubes; Dianqing Wu; Wenwen Tang
Journal:  Cell Rep       Date:  2017-06-20       Impact factor: 9.423

6.  Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes.

Authors:  Katsuya Kajimoto; Dan Shao; Hiromitsu Takagi; Gregorio Maceri; Daniela Zablocki; Hideyuki Mukai; Yoshitaka Ono; Junichi Sadoshima
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-10-29       Impact factor: 4.733

7.  Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression.

Authors:  Maddalena Grossi; Agnès Hiou-Feige; Alice Tommasi Di Vignano; Enzo Calautti; Paola Ostano; Sam Lee; Giovanna Chiorino; G Paolo Dotto
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-01       Impact factor: 11.205

8.  Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.

Authors:  Maxwell A Ruby; Isabelle Riedl; Julie Massart; Marcus Åhlin; Juleen R Zierath
Journal:  Am J Physiol Endocrinol Metab       Date:  2017-07-18       Impact factor: 4.310

9.  Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

Authors:  Youfei Guan; Yahua Zhang; Jing Wu; Zhonghua Qi; Guangrui Yang; Dou Dou; Yuansheng Gao; Lihong Chen; Xiaoyan Zhang; Linda S Davis; Mingfeng Wei; Xuefeng Fan; Monica Carmosino; Chuanming Hao; John D Imig; Richard M Breyer; Matthew D Breyer
Journal:  J Clin Invest       Date:  2007-09       Impact factor: 14.808

10.  Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.

Authors:  Teruhito Yasui; Kaori Sakakibara-Yada; Taki Nishimura; Kentaro Morita; Satoru Tada; George Mosialos; Elliott Kieff; Hitoshi Kikutani
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-05       Impact factor: 11.205
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