Literature DB >> 12761154

Involvement of nicotinic acetylcholine receptors in controlling Chlamydia pneumoniae growth in epithelial HEp-2 cells.

Hiroyuki Yamaguchi1, Herman Friedman, Yoshimasa Yamamoto.   

Abstract

Nicotinic acetylcholine receptors (nAChRs) play an essential role in neurotransmission. Recent studies have indicated that nAChRs may be involved in the regulation of some bacterial infections through immunological mechanisms in macrophages. However, the regulation of infection with Chlamydia pneumoniae, which is a ubiquitous pneumonia-causing bacterium, by an nAChR-mediated mechanism is still unclear. In the present study, it was found that stimulation of nAChRs with ligands such as nicotine and acetylcholine altered the growth of C. pneumoniae in epithelial HEp-2 cells. Thus, the results revealed a possible pathophysiological role of nAChRs in the regulation of intracellular bacterial infection.

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Year:  2003        PMID： 12761154      PMCID： PMC155782          DOI： 10.1128/IAI.71.6.3645-3647.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

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5.  Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team.

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Journal:  N Engl J Med       Date:  2000-03-09       Impact factor: 91.245

6.  Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells.

Authors:  H Klapproth; K Racké; I Wessler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1998-04       Impact factor: 3.000

7.  Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: evidence from a representative population survey.

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8.  Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

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9.  Chlamydia pneumoniae infects and multiplies in lymphocytes in vitro.

Authors:  S Haranaga; H Yamaguchi; H Friedman; S Izumi; Y Yamamoto
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

10.  Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patients.

Authors:  Marek Smieja; Richard Leigh; Astrid Petrich; Sylvia Chong; Dennis Kamada; Frederick E Hargreave; Charles H Goldsmith; Max Chernesky; James B Mahony
Journal:  BMC Infect Dis       Date:  2002-07-05       Impact factor: 3.090
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3.  Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor.

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5.  The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis.

Authors:  Leon Islas-Weinstein; Brenda Marquina-Castillo; Dulce Mata-Espinosa; Iris S Paredes-González; Jaime Chávez; Luciana Balboa; José Luis Marín Franco; Daniel Guerrero-Romero; Jorge Alberto Barrios-Payan; Rogelio Hernandez-Pando
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  5 in total

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