Literature DB >> 12761152

Cytolethal distending toxin gene cluster in enterohemorrhagic Escherichia coli O157:H- and O157:H7: characterization and evolutionary considerations.

Andreas Janka1, Martina Bielaszewska, Ulrich Dobrindt, Lilo Greune, M Alexander Schmidt, Helge Karch.   

Abstract

We identified a cytolethal distending toxin (cdt) gene cluster in 87, 6, and 0% of sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H(-), EHEC O157:H7, and E. coli O55:H7/H(-) strains, respectively. The toxin was expressed by the wild-type EHEC O157 strains and by a cdt-containing cosmid from a library of SF EHEC O157:H(-) strain 493/89. The cdt flanks in strain 493/89 were homologous to bacteriophages P2 and lambda. Our data demonstrate that cdt, encoding a potential virulence factor, is present in the EHEC O157 complex and suggest that cdt may have been acquired by phage transduction.

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Year:  2003        PMID： 12761152      PMCID： PMC155755          DOI： 10.1128/IAI.71.6.3634-3638.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

Review 1.  Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157:H(-) strains: epidemiology, phenotypic and molecular characteristics, and microbiological diagnosis.

Authors:  H Karch; M Bielaszewska
Journal:  J Clin Microbiol       Date:  2001-06       Impact factor: 5.948

2.  Novel type of fimbriae encoded by the large plasmid of sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H(-).

Authors:  W Brunder; A S Khan; J Hacker; H Karch
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

3.  Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.

Authors:  N T Perna; G Plunkett; V Burland; B Mau; J D Glasner; D J Rose; G F Mayhew; P S Evans; J Gregor; H A Kirkpatrick; G Pósfai; J Hackett; S Klink; A Boutin; Y Shao; L Miller; E J Grotbeck; N W Davis; A Lim; E T Dimalanta; K D Potamousis; J Apodaca; T S Anantharaman; J Lin; G Yen; D C Schwartz; R A Welch; F R Blattner
Journal:  Nature       Date:  2001-01-25       Impact factor: 49.962

4.  CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity.

Authors:  M Lara-Tejero; J E Galán
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

Review 5.  Shiga-toxin-converting bacteriophages.

Authors:  H Schmidt
Journal:  Res Microbiol       Date:  2001-10       Impact factor: 3.992

6.  Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.

Authors:  T Hayashi; K Makino; M Ohnishi; K Kurokawa; K Ishii; K Yokoyama; C G Han; E Ohtsubo; K Nakayama; T Murata; M Tanaka; T Tobe; T Iida; H Takami; T Honda; C Sasakawa; N Ogasawara; T Yasunaga; S Kuhara; T Shiba; M Hattori; H Shinagawa
Journal:  DNA Res       Date:  2001-02-28       Impact factor: 4.458

7.  Iha: a novel Escherichia coli O157:H7 adherence-conferring molecule encoded on a recently acquired chromosomal island of conserved structure.

Authors:  P I Tarr; S S Bilge; J C Vary; S Jelacic; R L Habeeb; T R Ward; M R Baylor; T E Besser
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

8.  [Hemolytic-uremic syndrome in infants due to verotoxin-producing Escherichia coli].

Authors:  H Karch; R Wiss; H Gloning; P Emmrich; S Aleksić; J Bockemühl
Journal:  Dtsch Med Wochenschr       Date:  1990-03-30       Impact factor: 0.628

9.  PCR for detection of cdt-III and the relative frequencies of cytolethal distending toxin variant-producing Escherichia coli isolates from humans and cattle.

Authors:  Clifford G Clark; Shelley T Johnson; Russell H Easy; Jennifer L Campbell; Frank G Rodgers
Journal:  J Clin Microbiol       Date:  2002-07       Impact factor: 5.948

10.  Identification and distribution of the enterohemorrhagic Escherichia coli factor for adherence (efa1) gene in sorbitol-fermenting Escherichia coli O157: H-.

Authors:  Andreas Janka; Martina Bielaszewska; Ulrich Dobrindt; Helge Karch
Journal:  Int J Med Microbiol       Date:  2002-09       Impact factor: 3.473
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  50 in total

Review 1.  Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion.

Authors:  Harald Brüssow; Carlos Canchaya; Wolf-Dietrich Hardt
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

2.  Characterization of cytolethal distending toxin genes and expression in shiga toxin-producing Escherichia coli strains of non-O157 serogroups.

Authors:  Martina Bielaszewska; Marina Fell; Lilo Greune; Rita Prager; Angelika Fruth; Helmut Tschäpe; M Alexander Schmidt; Helge Karch
Journal:  Infect Immun       Date:  2004-03       Impact factor: 3.441

Review 3.  Genome dynamics and its impact on evolution of Escherichia coli.

Authors:  Ulrich Dobrindt; M Geddam Chowdary; G Krumbholz; J Hacker
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

4.  Cytolethal distending toxin from Shiga toxin-producing Escherichia coli O157 causes irreversible G2/M arrest, inhibition of proliferation, and death of human endothelial cells.

Authors:  Martina Bielaszewska; Bhanu Sinha; Thorsten Kuczius; Helge Karch
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

5.  Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157: indications for an animal reservoir.

Authors:  D Orth; K Grif; M P Dierich; R Würzner
Journal:  Epidemiol Infect       Date:  2005-12-22       Impact factor: 2.451

6.  Bacteriophage-encoding cytolethal distending toxin type V gene induced from nonclinical Escherichia coli isolates.

Authors:  Anna Allué-Guardia; Cristina García-Aljaro; Maite Muniesa
Journal:  Infect Immun       Date:  2011-06-06       Impact factor: 3.441

Review 7.  Recent advances in understanding enteric pathogenic Escherichia coli.

Authors:  Matthew A Croxen; Robyn J Law; Roland Scholz; Kristie M Keeney; Marta Wlodarska; B Brett Finlay
Journal:  Clin Microbiol Rev       Date:  2013-10       Impact factor: 26.132

8.  Recycling of Shiga toxin 2 genes in sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM.

Authors:  Alexander Mellmann; Shan Lu; Helge Karch; Jian-guo Xu; Dag Harmsen; M Alexander Schmidt; Martina Bielaszewska
Journal:  Appl Environ Microbiol       Date:  2007-11-02       Impact factor: 4.792

9.  Use of diagnostic microarrays for determination of virulence gene patterns of Escherichia coli K1, a major cause of neonatal meningitis.

Authors:  Bozena Korczak; Joachim Frey; Jacques Schrenzel; Gerd Pluschke; Riccardo Pfister; Ralf Ehricht; Peter Kuhnert
Journal:  J Clin Microbiol       Date:  2005-03       Impact factor: 5.948

10.  Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli.

Authors:  István Tóth; Jean-Philippe Nougayrède; Ulrich Dobrindt; Terence Neil Ledger; Michèle Boury; Stefano Morabito; Tamaki Fujiwara; Motoyuki Sugai; Jörg Hacker; Eric Oswald
Journal:  Infect Immun       Date:  2008-11-03       Impact factor: 3.441
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