Literature DB >> 12760891

Alpha interferon augments cidofovir's antiviral and antiproliferative activities.

Jeffrey A Johnson1, J David Gangemi.   

Abstract

The antiviral and antiproliferative activities of alpha 2a interferon (IFN-alpha 2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-alpha 2a and cidofovir in inhibiting the proliferation of HPV-infected cells.

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Year:  2003        PMID: 12760891      PMCID: PMC155837          DOI: 10.1128/AAC.47.6.2022-2026.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  35 in total

1.  Selective inhibition of human papillomavirus-induced cell proliferation by (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.

Authors:  J A Johnson; J D Gangemi
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Therapeutic protocol of vulvar and cervical HPV-infection.

Authors:  R Zarcone; P Bellini; E Carfora; M Monarca; G Vicinanza; A Cardone
Journal:  Clin Exp Obstet Gynecol       Date:  1997       Impact factor: 0.146

3.  Cyclic HPMPC is safe and effective against systemic guinea pig cytomegalovirus infection in immune compromised animals.

Authors:  N Bourne; F J Bravo; D I Bernstein
Journal:  Antiviral Res       Date:  2000-08       Impact factor: 5.970

4.  Gilead issues new warnings about cidofovir nephrotoxicity.

Authors: 
Journal:  Am J Health Syst Pharm       Date:  1997-01-01       Impact factor: 2.637

5.  In vitro evaluation of combination therapies against hepatitis B virus replication.

Authors:  B E Korba
Journal:  Antiviral Res       Date:  1996-01       Impact factor: 5.970

6.  IFN-tau exhibits potent suppression of human papillomavirus E6/E7 oncoprotein expression.

Authors:  J A Johnson; H K Hochkeppel; J D Gangemi
Journal:  J Interferon Cytokine Res       Date:  1999-10       Impact factor: 2.607

7.  Successful treatment of severe respiratory papillomatosis with intravenous cidofovir and interferon alpha-2b.

Authors:  C Armbruster; A Kreuzer; H Vorbach; M Huber; C Armbruster
Journal:  Eur Respir J       Date:  2001-04       Impact factor: 16.671

8.  Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission.

Authors:  Z Mikloska; A L Cunningham
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

9.  Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].

Authors:  R Snoeck; W Wellens; C Desloovere; M Van Ranst; L Naesens; E De Clercq; L Feenstra
Journal:  J Med Virol       Date:  1998-03       Impact factor: 2.327

10.  Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon.

Authors:  B D Korant; D C Blomstrom; G J Jonak; E Knight
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

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