Literature DB >> 12760889

Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.

Baudouin Byl1, Frédérique Jacobs, Pierre Wallemacq, Camelia Rossi, Philippe de Francquen, Matteo Cappello, Teresinha Leal, Jean-Pierre Thys.   

Abstract

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

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Year:  2003        PMID： 12760889      PMCID： PMC155821          DOI： 10.1128/AAC.47.6.2015-2017.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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1.  Traditional weight-based vancomycin dosing is inadequate in critically ill trauma patients.

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Review 3.  Continuous versus intermittent intravenous administration of antibacterials with time-dependent action: a systematic review of pharmacokinetic and pharmacodynamic parameters.

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9.  Penetration of amphotericin B lipid formulations into pleural effusion.

Authors:  Stefan Weiler; Rosa Bellmann-Weiler; Michael Joannidis; Romuald Bellmann
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Review 10.  Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock--does the dose matter?

Authors:  Federico Pea; Pierluigi Viale
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