| Literature DB >> 12760309 |
K Matsuo1, M Oka, K Murase, H Soda, H Isomoto, F Takeshima, Y Mizuta, I Murata, S Kohno.
Abstract
Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions. The present study was designed to determine the expression of IL-6 and its receptor (IL-6R) in human gastric and colorectal cancers. Nine gastric- and nine colorectal cancer cell lines were analysed. The IL-6 gene was expressed in two gastric cancer cell lines and one colorectal cancer cell line; however, most of the cancer cell lines studied expressed the IL-6R gene. The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< approximately 100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines (< approximately 50 pg/ml). These results suggest that IL-6 may act in a paracrine fashion rather than an autocrine fashion in these cell lines.Entities:
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Year: 2003 PMID： 12760309 DOI： 10.1177/147323000303100202
Source DB: PubMed Journal: J Int Med Res ISSN： 0300-0605 Impact factor: 1.671