Literature DB >> 1275883

Chemical nature and sequence of alamethicin.

D R Martin, R J Williams.   

Abstract

An n.m.r. spectroscopy study of pure alamethicin shows it to be a linear polypeptide of 19 residues. The N-terminus is blocked by an acetyl group, and the eighteenth residue, glutamic acid, is linked by an amide bond on its side chain to phenylalaninol (Fig. 6). The new formula is confirmed by a comparison between pure chemical compounds and the products of partial hydrolysis.

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Year:  1976        PMID： 1275883      PMCID： PMC1172561          DOI： 10.1042/bj1530181

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  Physical and chemical studies of gramicidin and some implications for the study of proteins.

Authors:  R L M SYNGE
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1950

2.  A polypeptide antibacterial agent isolated from Trichoderma viride.

Authors:  C E Meyer; F Reusser
Journal:  Experientia       Date:  1967-02-15

3.  The unit conductance channel of alamethicin.

Authors:  L G Gordon; D A Haydon
Journal:  Biochim Biophys Acta       Date:  1972-03-17

4.  Resting and action potentials in experimental bimolecular lipid membranes.

Authors:  P Mueller; D O Rudin
Journal:  J Theor Biol       Date:  1968-02       Impact factor: 2.691

5.  The hydroxyamino component of gramicidin hydrolysates.

Authors:  R L Synge
Journal:  Biochem J       Date:  1945       Impact factor: 3.857

6.  The primary structure of alamethicin.

Authors:  J W Payne; R Jakes; B S Hartley
Journal:  Biochem J       Date:  1970-05       Impact factor: 3.857
  6 in total
  10 in total

1.  Pore formation in lipid membranes by alamethicin.

Authors:  U P Fringeli; M Fringeli
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

2.  Alamethicin-induced conductances in lipid bilayers: I. Data analysis and simple steady-state model.

Authors:  M Fleischmann; C Gabrielli; M T Labram; A I McMullen; T H Wilmshurst
Journal:  J Membr Biol       Date:  1980-06-30       Impact factor: 1.843

Review 3.  Model ion channels: gramicidin and alamethicin.

Authors:  G A Woolley; B A Wallace
Journal:  J Membr Biol       Date:  1992-08       Impact factor: 1.843

4.  Conformational changes in alamethicin associated with substitution of its alpha-methylalanines with leucines: a FTIR spectroscopic analysis and correlation with channel kinetics.

Authors:  Parvez I Haris; Gérard Molle; Hervé Duclohier
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

Review 5.  Alamethicin and related membrane channel forming polypeptides.

Authors:  M K Mathew; P Balaram
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

6.  Pancuronium inactivates alamethicin-induced conductance in artificial membranes.

Authors:  J J Donovan; R Latorre
Journal:  Biophys J       Date:  1979-03       Impact factor: 4.033

7.  Synthesis of a 19-residue peptide with alamethicin-like activity.

Authors:  B F Gisin; S Kobayashi; J E Hall
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

8.  Accelerated Molecular Dynamics Applied to the Peptaibol Folding Problem.

Authors:  Chetna Tyagi; Tamás Marik; Csaba Vágvölgyi; László Kredics; Ferenc Ötvös
Journal:  Int J Mol Sci       Date:  2019-08-30       Impact factor: 5.923

9.  Mechanisms of peptide-induced pore formation in lipid bilayers investigated by oriented 31P solid-state NMR spectroscopy.

Authors:  Kresten Bertelsen; Jerzy Dorosz; Sara Krogh Hansen; Niels Chr Nielsen; Thomas Vosegaard
Journal:  PLoS One       Date:  2012-10-18       Impact factor: 3.240

10.  Inactivation of the alamethicin-induced conductance caused by quaternary ammonium ions and local anesthetics.

Authors:  J J Donovan; R Latorre
Journal:  J Gen Physiol       Date:  1979-04       Impact factor: 4.086
  10 in total

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