Literature DB >> 12758284

Lipid metabolism in Plasmodium falciparum-infected erythrocytes: possible new targets for malaria chemotherapy.

Toshihide Mitamura1, Nirianne Marie Q Palacpac.   

Abstract

The emergence and spread of drug-resistant parasites coupled with the absence of an effective vaccine makes malaria treatment more complicated, and thus the development of new antimalarial drugs is one of the urgent tasks in malaria research. This review highlights lipid metabolism in Plasmodium parasite cells, the study of which would lead to providing new targets for therapeutic intervention.

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Year:  2003        PMID： 12758284     DOI： 10.1016/s1286-4579(03)00070-4

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  12 in total

1.  The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy.

Authors:  Anh N Hoang; Rebecca D Sandlin; Aneesa Omar; Timothy J Egan; David W Wright
Journal:  Biochemistry       Date:  2010-11-08       Impact factor: 3.162

Review 2.  Patatin-like phospholipases in microbial infections with emerging roles in fatty acid metabolism and immune regulation by Apicomplexa.

Authors:  Sarah K Wilson; Laura J Knoll
Journal:  Mol Microbiol       Date:  2017-11-23       Impact factor: 3.501

3.  In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.

Authors:  Luiz Francisco Rocha e Silva; Karla Lagos Nogueira; Ana Cristina da Silva Pinto; Alejandro Miguel Katzin; Rodrigo A C Sussmann; Magno Perêa Muniz; Valter Ferreira de Andrade Neto; Francisco Célio Maia Chaves; Julia Penna Coutinho; Emerson Silva Lima; Antoniana Ursine Krettli; Wanderli Pedro Tadei; Adrian Martin Pohlit
Journal:  Antimicrob Agents Chemother       Date:  2015-03-23       Impact factor: 5.191

Review 4.  Role of phospholipid synthesis in the development and differentiation of malaria parasites in the blood.

Authors:  Nicole Kilian; Jae-Yeon Choi; Dennis R Voelker; Choukri Ben Mamoun
Journal:  J Biol Chem       Date:  2018-10-04       Impact factor: 5.157

5.  A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation.

Authors:  Gabriella Pessi; Guillermo Kociubinski; Choukri Ben Mamoun
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

6.  Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface.

Authors:  Sarah Frankland; Salenna R Elliott; Francisca Yosaatmadja; James G Beeson; Stephen J Rogerson; Akinola Adisa; Leann Tilley
Journal:  Eukaryot Cell       Date:  2007-07-20

7.  A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase.

Authors:  Han Gao; Liang Bai; Yongmao Jiang; Wei Huang; Lili Wang; Shengguo Li; Guoding Zhu; Duoquan Wang; Zhenghui Huang; Xishang Li; Jun Cao; Lubing Jiang; Marcelo Jacobs-Lorena; Shuai Zhan; Sibao Wang
Journal:  Nat Microbiol       Date:  2021-05-06       Impact factor: 17.745

8.  Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism.

Authors:  Susanna Bazzani; Andreas Hoppe; Hermann-Georg Holzhütter
Journal:  BMC Syst Biol       Date:  2012-08-31

9.  Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

Authors:  Paul Gratraud; Enlli Huws; Brie Falkard; Sophie Adjalley; David A Fidock; Laurence Berry; William R Jacobs; Mark S Baird; Henri Vial; Laurent Kremer
Journal:  PLoS One       Date:  2009-09-03       Impact factor: 3.240

10.  Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection.

Authors:  Dora Posfai; Kayla Sylvester; Anupama Reddy; Jack G Ganley; Johannes Wirth; Quinlan E Cullen; Tushar Dave; Nobutaka Kato; Sandeep S Dave; Emily R Derbyshire
Journal:  PLoS Pathog       Date:  2018-05-18       Impact factor: 6.823
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