Literature DB >> 12757976

Telomeres in cancer and aging: lessons from the mouse.

María A Blasco1.   

Abstract

The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively.

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Year:  2003        PMID： 12757976     DOI： 10.1016/s0304-3835(02)00705-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival.

Authors:  Marina Tarunina; Lynsey Alger; Grace Chu; Karl Munger; Andrei Gudkov; Parmjit S Jat
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

2.  Function, replication and structure of the mammalian telomere.

Authors:  Dominique Broccoli
Journal:  Cytotechnology       Date:  2004-06       Impact factor: 2.058

Review 3.  Mechanisms of DNA damage, repair, and mutagenesis.

Authors:  Nimrat Chatterjee; Graham C Walker
Journal:  Environ Mol Mutagen       Date:  2017-05-09       Impact factor: 3.216

4.  Increased p53 activity does not accelerate telomere-driven ageing.

Authors:  Isabel García-Cao; Marta García-Cao; Antonia Tomás-Loba; Juan Martín-Caballero; Juana M Flores; Peter Klatt; María A Blasco; Manuel Serrano
Journal:  EMBO Rep       Date:  2006-03-31       Impact factor: 8.807

5.  Epigallocatechin-3-gallate decreases UVA-induced HPRT mutations in human skin fibroblasts accompanied by increased rates of senescence and apoptosis.

Authors:  Yang Xu; Jie Zhu; Bingrong Zhou; Dan Luo
Journal:  Exp Ther Med       Date:  2012-01-31       Impact factor: 2.447

Review 6.  Telomerase and its potential for therapeutic intervention.

Authors:  P Phatak; A M Burger
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739

7.  Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.

Authors:  P Phatak; J C Cookson; F Dai; V Smith; R B Gartenhaus; M F G Stevens; A M Burger
Journal:  Br J Cancer       Date:  2007-04-03       Impact factor: 7.640

Review 8.  Potential of telomerase activation in extending health span and longevity.

Authors:  Bruno Bernardes de Jesus; Maria A Blasco
Journal:  Curr Opin Cell Biol       Date:  2012-10-18       Impact factor: 8.382

9.  Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.

Authors:  Silvia Espejel; Peter Klatt; Josiane Ménissier-de Murcia; Juan Martín-Caballero; Juana M Flores; Guillermo Taccioli; Gilbert de Murcia; María A Blasco
Journal:  J Cell Biol       Date:  2004-11-15       Impact factor: 10.539
  9 in total

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