| Literature DB >> 12757938 |
David A Taylor-Fishwick1, Sharon Rittman, Hidayah Kendall, Lipika Roy, Wenjing Shi, Yong Cao, Gary L Pittenger, Aaron I Vinik.
Abstract
The protein product of hamster islet neogenesis-associated protein (INGAP) cDNA induces new pancreatic islet development. Manipulation of this process provides a new therapeutic strategy for the treatment of diabetes. As regulators of INGAP gene expression are unknown over 6 kb of hamster genomic INGAP has been cloned. Sequence analysis has identified a 3 kb 5-prime region with core promoter elements that is rich in transcription factor binding sites and six exons for the coding region. Analysis of promoter activity reveals stimulus-responsive DNA elements which have been identified though deletion analysis. Comparison of transcription factor binding sites in INGAP to the related gene RegIIIdelta exposes potential sites for differential gene regulation.Entities:
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Year: 2003 PMID： 12757938 DOI： 10.1016/s0925-4439(03)00042-5
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002