Literature DB >> 12757716

Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives.

Mauricio A Cuellar1, Cristian Salas, Manuel J Cortés, Antonio Morello, Juan Diego Maya, Marcelo D Preite.   

Abstract

The Diels-Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagas' disease.

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Year:  2003        PMID： 12757716     DOI： 10.1016/s0968-0896(03)00193-7

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima.

Authors:  Priscilla L Winder; Heather L Baker; Patricia Linley; Esther A Guzmán; Shirley A Pomponi; M Cristina Diaz; John K Reed; Amy E Wright
Journal:  Bioorg Med Chem       Date:  2011-09-21       Impact factor: 3.641

2.  Application of linear discriminant analysis in the virtual screening of antichagasic drugs through trypanothione reductase inhibition.

Authors:  Julián J Prieto; Alan Talevi; Luis E Bruno-Blanch
Journal:  Mol Divers       Date:  2006-09-21       Impact factor: 2.943

Review 3.  Synthetic strategies to terpene quinones/hydroquinones.

Authors:  Marina Gordaliza
Journal:  Mar Drugs       Date:  2012-02-14       Impact factor: 6.085

4.  Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients.

Authors:  Víctor Marín; Bryan Bart; Nicole Cortez; Verónica A Jiménez; Víctor Silva; Oscar Leyton; Jaime R Cabrera-Pardo; Bernd Schmidt; Matthias Heydenreich; Viviana Burgos; Cristian Paz
Journal:  Int J Mol Sci       Date:  2022-10-04       Impact factor: 6.208

5.  Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

Authors:  Daniel Spinks; Emma J Shanks; Laura A T Cleghorn; Stuart McElroy; Deuan Jones; Daniel James; Alan H Fairlamb; Julie A Frearson; Paul G Wyatt; Ian H Gilbert
Journal:  ChemMedChem       Date:  2009-12       Impact factor: 3.466

6.  Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies.

Authors:  Marcos Derita; Iván Montenegro; Francisco Garibotto; Ricardo D Enriz; Mauricio Cuellar Fritis; Susana A Zacchino
Journal:  Molecules       Date:  2013-02-05       Impact factor: 4.411

7.  Synthesis of a new ent-cyclozonarone angular analog, and comparison of its cytotoxicity and apoptotic effects with ent-cyclozonarone.

Authors:  Natalia Quiñones Sobarzo; Iván Montenegro Venegas; Cristian Salas Sánchez; Luis Espinoza Catalán; Cristóbal Carrasco Rojas; Valentina Ulloa Valdivia; Joan Villena García; Mauricio Cuellar Fritis
Journal:  Molecules       Date:  2013-05-13       Impact factor: 4.411
  7 in total

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