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Literature DB >> 12756395

Glutathione metabolism and antioxidant enzymes in children with Down syndrome.

Anna Pastore¹, Giulia Tozzi, Laura Maria Gaeta, Aldo Giannotti, Enrico Bertini, Giorgio Federici, Maria Cristina Digilio, Fiorella Piemonte.

Abstract

Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12756395 DOI： 10.1067/mpd.2003.203

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

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Cited

10 in total

1. Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.

Authors: Gail D Zeevalk; Laura P Bernard; F T Guilford
Journal: Neurochem Res Date: 2010-06-10 Impact factor: 3.996

2. Regular exercise did not modify significantly superoxide dismutase activity in adolescents with Down's syndrome.

Authors: F J Ordoñez; M Rosety; M Rosety-Rodriguez
Journal: Br J Sports Med Date: 2006-08 Impact factor: 13.800

Review 3. S-glutathionylation: from redox regulation of protein functions to human diseases.

Authors: Daniela Giustarini; R Rossi; A Milzani; R Colombo; Isabella Dalle-Donne
Journal: J Cell Mol Med Date: 2004 Apr-Jun Impact factor: 5.310

4. The Redox Potential of the β-⁹³-Cysteine Thiol Group in Human Hemoglobin Estimated from In Vitro Oxidant Challenge Experiments.

Authors: Federico Maria Rubino
Journal: Molecules Date: 2021-04-26 Impact factor: 4.411

Glutathione metabolism and antioxidant enzymes in children with Down syndrome.

1. Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.

2. Regular exercise did not modify significantly superoxide dismutase activity in adolescents with Down's syndrome.

Review 3. S-glutathionylation: from redox regulation of protein functions to human diseases.

4. The Redox Potential of the β-⁹³-Cysteine Thiol Group in Human Hemoglobin Estimated from In Vitro Oxidant Challenge Experiments.

5. Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism.

Review 6. Glutathione as a Redox Biomarker in Mitochondrial Disease-Implications for Therapy.

7. Catalase from larvae of the camel tick Hyalomma dromedarii.

Review 8. Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse.

9. Redox processes in neurodegenerative disease involving reactive oxygen species.

10. Glutathione imbalance in patients with X-linked adrenoleukodystrophy.