Literature DB >> 12756225

Mice lacking a transcriptional corepressor Tob are predisposed to cancer.

Yutaka Yoshida1, Takahisa Nakamura, Masato Komoda, Hitoshi Satoh, Toru Suzuki, Junko K Tsuzuku, Takashi Miyasaka, Eri H Yoshida, Hisashi Umemori, Reiko K Kunisaki, Kenzaburo Tani, Shunsuke Ishii, Shigeo Mori, Masami Suganuma, Tetsuo Noda, Tadashi Yamamoto.   

Abstract

tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob(-/-) mice than in wild-type mice. tob(-/-)p53(-/-) mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase. Levels of tob mRNA are often decreased in human cancers, implicating tob in cancer development.

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Year:  2003        PMID： 12756225      PMCID： PMC196063          DOI： 10.1101/gad.1088003

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  34 in total

1.  Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters.

Authors:  B S Fletcher; R W Lim; B C Varnum; D A Kujubu; R A Koski; H R Herschman
Journal:  J Biol Chem       Date:  1991-08-05       Impact factor: 5.157

2.  Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

Authors:  A Bradbury; R Possenti; E M Shooter; F Tirone
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

3.  Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

Authors:  S Miyake; M Makimura; Y Kanegae; S Harada; Y Sato; K Takamori; C Tokuda; I Saito
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-06       Impact factor: 11.205

4.  Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.

Authors:  D Tzachanis; G J Freeman; N Hirano; A A van Puijenbroek; M W Delfs; A Berezovskaya; L M Nadler; V A Boussiotis
Journal:  Nat Immunol       Date:  2001-12       Impact factor: 25.606

5.  Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle.

Authors:  F Guéhenneux; L Duret; M B Callanan; R Bouhas; S Hayette; C Berthet; C Samarut; R Rimokh; A M Birot; Q Wang; J P Magaud; J P Rouault
Journal:  Leukemia       Date:  1997-03       Impact factor: 11.528

6.  Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

Authors:  M Harvey; M J McArthur; C A Montgomery; J S Butel; A Bradley; L A Donehower
Journal:  Nat Genet       Date:  1993-11       Impact factor: 38.330

7.  Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.

Authors:  Toru Suzuki; Junko K-Tsuzuku; Rieko Ajima; Takahisa Nakamura; Yutaka Yoshida; Tadashi Yamamoto
Journal:  Genes Dev       Date:  2002-06-01       Impact factor: 11.361

8.  Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

Authors:  S Matsuda; J Kawamura-Tsuzuku; M Ohsugi; M Yoshida; M Emi; Y Nakamura; M Onda; Y Yoshida; A Nishiyama; T Yamamoto
Journal:  Oncogene       Date:  1996-02-15       Impact factor: 9.867

9.  BTG1, a member of a new family of antiproliferative genes.

Authors:  J P Rouault; R Rimokh; C Tessa; G Paranhos; M Ffrench; L Duret; M Garoccio; D Germain; J Samarut; J P Magaud
Journal:  EMBO J       Date:  1992-04       Impact factor: 11.598

10.  Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.

Authors:  D C Betticher; J Heighway; P S Hasleton; H J Altermatt; W D Ryder; T Cerny; N Thatcher
Journal:  Br J Cancer       Date:  1996-02       Impact factor: 7.640
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  38 in total

1.  xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.

Authors:  Oliver Wessely; James I Kim; Uyen Tran; Luis Fuentealba; E M De Robertis
Journal:  Dev Biol       Date:  2005-07-01       Impact factor: 3.582

2.  Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation.

Authors:  Yuxia Zhang; Ping Xu; Kyungtae Park; Yunhee Choi; David D Moore; Li Wang
Journal:  Hepatology       Date:  2008-07       Impact factor: 17.425

3.  The role of the TOB1 gene in growth suppression of hepatocellular carcinoma.

Authors:  Sheyu Lin; Qingfeng Zhu; Yang Xu; Hui Liu; Junyu Zhang; Jiawei Xu; Honglian Wang; Qing Sang; Qinghe Xing; Jia Fan
Journal:  Oncol Lett       Date:  2012-08-16       Impact factor: 2.967

4.  Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.

Authors:  Toru Suzuki; Junko Tsuzuku; Akiyo Hayashi; Yasushi Shiomi; Hiroko Iwanari; Yasuhiro Mochizuki; Takao Hamakubo; Tatsuhiko Kodama; Hideo Nishitani; Hisao Masai; Tadashi Yamamoto
Journal:  J Biol Chem       Date:  2012-10-12       Impact factor: 5.157

5.  Flipping the switch from g1 to s phase with e3 ubiquitin ligases.

Authors:  Lindsay F Rizzardi; Jeanette Gowen Cook
Journal:  Genes Cancer       Date:  2012-11

6.  The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

Authors:  Akhmed Aslam; Saloni Mittal; Frederic Koch; Jean-Christophe Andrau; G Sebastiaan Winkler
Journal:  Mol Biol Cell       Date:  2009-07-15       Impact factor: 4.138

7.  Tob1 is a constitutively expressed repressor of liver regeneration.

Authors:  Karen J Ho; Nhue L Do; Hasan H Otu; Martin J Dib; Xianghui Ren; Keiichi Enjyoji; Simon C Robson; Ernest F Terwilliger; Seth J Karp
Journal:  J Exp Med       Date:  2010-05-31       Impact factor: 14.307

8.  Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.

Authors:  Akinori Takahashi; Masahiro Morita; Kazumasa Yokoyama; Toru Suzuki; Tadashi Yamamoto
Journal:  Mol Cell Biol       Date:  2012-10-15       Impact factor: 4.272

9.  Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.

Authors:  Masataka Horiuchi; Kosei Takeuchi; Nobuo Noda; Nobuyuki Muroya; Toru Suzuki; Takahisa Nakamura; Junko Kawamura-Tsuzuku; Kiyohiro Takahasi; Tadashi Yamamoto; Fuyuhiko Inagaki
Journal:  J Biol Chem       Date:  2009-03-10       Impact factor: 5.157

Review 10.  Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.

Authors:  Dimitrios Tzachanis; Vassiliki A Boussiotis
Journal:  Cell Cycle       Date:  2009-04-30       Impact factor: 4.534
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