Literature DB >> 12754936

Genetic regulation networks: circuits, regulons and attractors.

Jacques Demongeot1, Julio Aracena, Florence Thuderoz, Thierry-Pascal Baum, Olivier Cohen.   

Abstract

We deal in this paper with the concept of genetic regulation network. The genes expression observed through the bio-array imaging allows the geneticist to obtain the intergenic interaction matrix W of the network. The interaction graph G associated to W presents in general interesting features like connected components, gardens of Eden, positive and negative circuits (or loops), and minimal components having 1 positive and 1 negative loop called regulons. Depending on parameters values like the connectivity coefficient K(W) and the mean inhibition weight I(W), the genetic regulation network can present several dynamical behaviours (fixed configuration, limit cycle of configurations) called attractors, when the observation time increases. We give some examples of such genetic regulation networks and analyse their dynamical properties and their biological consequences.

Mesh:

Year:  2003        PMID: 12754936     DOI: 10.1016/s1631-0691(03)00069-6

Source DB:  PubMed          Journal:  C R Biol        ISSN: 1631-0691            Impact factor:   1.583


  2 in total

1.  Piecewise-linear models of genetic regulatory networks: equilibria and their stability.

Authors:  Richard Casey; Hidde de Jong; Jean-Luc Gouzé
Journal:  J Math Biol       Date:  2005-09-29       Impact factor: 2.259

2.  Geometric properties of a class of piecewise affine biological network models.

Authors:  Etienne Farcot
Journal:  J Math Biol       Date:  2005-12-28       Impact factor: 2.164

  2 in total

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