Literature DB >> 12753664

HFE, the MHC and hemochromatosis: paradigm for an extended function for MHC class I.

C S Cardoso1, M de Sousa.   

Abstract

HFE was discovered as the hereditary hemochromatosis (HH) gene. It is located on chromosome 6 (6p21.3), 4Mb telomeric to the HLA-A locus, and its product has a structure similar to MHC class I molecules. HFE encodes two frequent mutations: C282Y and H63D. One of these (C282Y) is present in a large proportion of Caucasian HH patients. HFE has a tissue distribution compatible with a role in iron absorption (intestine), recycling (macrophages) and transport to the fetus (placenta).

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Year:  2003        PMID： 12753664     DOI： 10.1034/j.1399-0039.2003.00065.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  12 in total

1.  Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism.

Authors:  Jonathan W Yewdell; Heather D Hickman-Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-29       Impact factor: 11.205

2.  MHC molecules in health and disease: At the cusp of a paradigm shift.

Authors:  Denise E de Almeida; Joseph Holoshitz
Journal:  Self Nonself       Date:  2011-01-01

3.  Bayesian graphical network analyses reveal complex biological interactions specific to Alzheimer's disease.

Authors:  Alan Rembach; Francesco C Stingo; Christine Peterson; Marina Vannucci; Kim-Anh Do; William J Wilson; S Lance Macaulay; Timothy M Ryan; Ralph N Martins; David Ames; Colin L Masters; James D Doecke
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

Review 4.  Iron overload and immunity.

Authors:  Graça Porto; Maria De Sousa
Journal:  World J Gastroenterol       Date:  2007-09-21       Impact factor: 5.742

Review 5.  Recent advances in understanding haemochromatosis: a transition state.

Authors:  K J H Robson; A T Merryweather-Clarke; E Cadet; V Viprakasit; M G Zaahl; J J Pointon; D J Weatherall; J Rochette
Journal:  J Med Genet       Date:  2004-10       Impact factor: 6.318

6.  Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin.

Authors:  Jena D French; Christina L Roark; Willi K Born; Rebecca L O'Brien
Journal:  J Immunol       Date:  2009-02-15       Impact factor: 5.422

7.  Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction.

Authors:  Mazell M Tetruashvily; John W Melson; Joseph J Park; Xiaoyu Peng; Lisa M Boulanger
Journal:  Mol Cell Neurosci       Date:  2016-01-21       Impact factor: 4.314

8.  Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.

Authors:  Thomas Herrmann; Martina Muckenthaler; Frank van der Hoeven; Karen Brennan; Sven G Gehrke; Nadia Hubert; Consolato Sergi; Hermann-Josef Gröne; Iris Kaiser; Isabella Gosch; Martin Volkmann; Hans-Dieter Riedel; Matthias W Hentze; A Francis Stewart; Wolfgang Stremmel
Journal:  J Mol Med (Berl)       Date:  2003-11-15       Impact factor: 4.599

Review 9.  HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease.

Authors:  Fatima Ali-Rahmani; Cara-Lynne Schengrund; James R Connor
Journal:  Front Pharmacol       Date:  2014-07-08       Impact factor: 5.810

10.  Differential geometric analysis of alterations in MH α-helices.

Authors:  Birgit Hischenhuber; Hans Havlicek; Jelena Todoric; Sonja Höllrigl-Binder; Wolfgang Schreiner; Bernhard Knapp
Journal:  J Comput Chem       Date:  2013-05-24       Impact factor: 3.376
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