BACKGROUND: Cardiovascular disease is the main cause of morbidity and mortality among hemodialysis patients. Chronic renal failure influences a number of factors that cause accelerated atherogenesis, with calcium, phosphorus, and PTH playing key roles. Several studies have demonstrated the influence of these factors on all-cause and cardiovascular mortality in the American hemodialysis population. In the present study we evaluated the variables that influence long-term cardiovascular mortality in a European hemodialysis population. METHODS: One hundred and forty-three hemodialysis patients were followed for six years. Several Cox models were used to study the influence of demographic and biochemical data, and comorbid conditions in cardiovascular survival, with a particular interest in mineral metabolism. RESULTS: There was an increased risk of cardiovascular death in patients with serum P>6.5 mg/dL (risk ratio [RR], 2.5), PTH>50 pmol/L (RR, 3.9), Ca x P>52 (RR, 2.8), BB or Bb genotype (RR, 3.8), and in diabetics. CONCLUSION: There is a stronger influence of mineral metabolism on cardiovascular death among European patients when compared to the American population.
BACKGROUND:Cardiovascular disease is the main cause of morbidity and mortality among hemodialysis patients. Chronic renal failure influences a number of factors that cause accelerated atherogenesis, with calcium, phosphorus, and PTH playing key roles. Several studies have demonstrated the influence of these factors on all-cause and cardiovascular mortality in the American hemodialysis population. In the present study we evaluated the variables that influence long-term cardiovascular mortality in a European hemodialysis population. METHODS: One hundred and forty-three hemodialysis patients were followed for six years. Several Cox models were used to study the influence of demographic and biochemical data, and comorbid conditions in cardiovascular survival, with a particular interest in mineral metabolism. RESULTS: There was an increased risk of cardiovascular death in patients with serum P>6.5 mg/dL (risk ratio [RR], 2.5), PTH>50 pmol/L (RR, 3.9), Ca x P>52 (RR, 2.8), BB or Bb genotype (RR, 3.8), and in diabetics. CONCLUSION: There is a stronger influence of mineral metabolism on cardiovascular death among European patients when compared to the American population.
Authors: Hee Jung Jeon; Yong Chul Kim; Seokwoo Park; Clara Tammy Kim; Jongwon Ha; Duck Jong Han; Jieun Oh; Chun Soo Lim; In Mok Jung; Curie Ahn; Yon Su Kim; Jung Pyo Lee; Young Hoon Kim Journal: Clin J Am Soc Nephrol Date: 2017-02-03 Impact factor: 8.237
Authors: Andrea Trombetti; Catherine Stoermann; John H Robert; François R Herrmann; Pietra Pennisi; Pierre-Yves Martin; René Rizzoli Journal: World J Surg Date: 2007-05 Impact factor: 3.352
Authors: Jaime L Natoli; Rob Boer; Brian H Nathanson; Ross M Miller; Silvia Chiroli; William G Goodman; Vasily Belozeroff Journal: BMC Nephrol Date: 2013-04-17 Impact factor: 2.388