OBJECTIVE: Several, but not all epidemiological studies, have demonstrated a positive correlation between exposure to the virus during the second trimester of pregnancy and an increased risk to the infants for subsequently developing schizophrenia. The present study is the first be designed in France to examine the risk of gestational exposure to the influenza virus and subsequent development of schizophrenia. METHOD: A total of 974 adults with schizophrenia born between 1949 and 1981 were compared for risk of exposure to influenza with their non-schizophrenic siblings and with matched control patients. RESULTS: Significantly more schizophrenic subjects than controls (both groups) had been exposed to the influenza virus during the fifth month of pregnancy (OR=2.24, CI: 1.49-3.35, and OR=1.61, CI: 1.04-2.49). CONCLUSION: These results suggest that influenza infection during pregnancy is a neurodevelopmental risk factor for schizophrenia in adult life.
OBJECTIVE: Several, but not all epidemiological studies, have demonstrated a positive correlation between exposure to the virus during the second trimester of pregnancy and an increased risk to the infants for subsequently developing schizophrenia. The present study is the first be designed in France to examine the risk of gestational exposure to the influenza virus and subsequent development of schizophrenia. METHOD: A total of 974 adults with schizophrenia born between 1949 and 1981 were compared for risk of exposure to influenza with their non-schizophrenic siblings and with matched control patients. RESULTS: Significantly more schizophrenic subjects than controls (both groups) had been exposed to the influenza virus during the fifth month of pregnancy (OR=2.24, CI: 1.49-3.35, and OR=1.61, CI: 1.04-2.49). CONCLUSION: These results suggest that influenza infection during pregnancy is a neurodevelopmental risk factor for schizophrenia in adult life.
Authors: Juan A Gallego; Emily A Blanco; Sehba Husain-Krautter; E Madeline Fagen; Paula Moreno-Merino; Juan A Del Ojo-Jiménez; Anthony Ahmed; Thomas L Rothstein; Todd Lencz; Anil K Malhotra Journal: Schizophr Res Date: 2018-07-17 Impact factor: 4.939
Authors: Neil M Richtand; Rebecca Ahlbrand; Paul Horn; Kevin Stanford; Stefanie L Bronson; Robert K McNamara Journal: J Psychiatr Res Date: 2011-03-25 Impact factor: 4.791
Authors: Qi Li; Charlton Cheung; Ran Wei; Edward S Hui; Joram Feldon; Urs Meyer; Sookja Chung; Siew E Chua; Pak C Sham; Ed X Wu; Grainne M McAlonan Journal: PLoS One Date: 2009-07-24 Impact factor: 3.240
Authors: Emily G Severance; Faith B Dickerson; Raphael P Viscidi; Ioannis Bossis; Cassie R Stallings; Andrea E Origoni; Anne Sullens; Robert H Yolken Journal: Schizophr Bull Date: 2009-06-02 Impact factor: 9.306