P E B Hansen1, A G Wang, K B Stage, P Kragh-Sorensen. 1. Department of Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Aarhus, Denmark. peh@psykiatri.aaa.dk
Abstract
OBJECTIVE: To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. METHOD: A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. RESULTS: The suicide rate for non-melancholic depressed patients was significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15-10.10)]. CONCLUSION: The study indicates that the non-melancholic aspect of depression, and especially comorbid personality disorder, is associated with an increased suicidal vulnerability.
RCT Entities:
OBJECTIVE: To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. METHOD: A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. RESULTS: The suicide rate for non-melancholic depressedpatients was significantly higher than for melancholic depressedpatients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15-10.10)]. CONCLUSION: The study indicates that the non-melancholic aspect of depression, and especially comorbid personality disorder, is associated with an increased suicidal vulnerability.
Authors: Maria A Oquendo; Juan Jose Carballo; Namita Rajouria; Dianne Currier; Adrienne Tin; Jessica Merville; Hanga C Galfalvy; Leo Sher; Michael F Grunebaum; Ainsley K Burke; J John Mann Journal: Arch Suicide Res Date: 2009
Authors: Craig H Mallinckrodt; John G Watkin; Chaofeng Liu; Madelaine M Wohlreich; Joel Raskin Journal: BMC Psychiatry Date: 2005-01-04 Impact factor: 3.630