| Literature DB >> 12751042 |
Yasuhito Tanaka1, Takahisa Furuta, Seiji Suzuki, Etsuro Orito, Anthony E T Yeo, Noboru Hirashima, Fuminaka Sugauchi, Ryuzo Ueda, Masashi Mizokami.
Abstract
To examine the effects of polymorphisms in the gene encoding proinflammatory interleukin (IL)-1beta in patients infected with hepatitis C virus (HCV) in Japan, we studied 364 patients with chronic HCV infection (146 of whom had hepatocellular carcinoma [HCC] and 218 of whom did not) and 230 healthy control subjects. IL-1B-511 and IL-1RN genotypes were ascertained, and IL-1B-511 genotype T/T was found to be significant risk factors for the development of HCC, indicating that polymorphism in the IL-1B-511 genetic locus is one of the possible determinants of progression of hepatitis C to HCC.Entities:
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Year: 2003 PMID： 12751042 DOI： 10.1086/375248
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226