BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS: Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS: MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.
BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in strokepatients. METHODS: Plasma samples from 23 strokepatients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS:MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.
Authors: Kyung Yul Lee; Dong Ik Kim; Seo Hyun Kim; Seung Ik Lee; Hae Woong Chung; Yong Woon Shim; Seung Min Kim; Ji Hoe Heo Journal: AJNR Am J Neuroradiol Date: 2004-10 Impact factor: 3.825
Authors: John R Sims; Guy Rordorf; Eric E Smith; Walter J Koroshetz; Michael H Lev; Ferdinando Buonanno; Lee H Schwamm Journal: AJNR Am J Neuroradiol Date: 2005-02 Impact factor: 3.825
Authors: Shanyan Chen; Jiankun Cui; Tao Jiang; Emilia S Olson; Quan-Yu Cai; Ming Yang; Wei Wu; James M Guthrie; J D Robertson; Stuart A Lipton; Lixin Ma; Roger Y Tsien; Zezong Gu Journal: J Cereb Blood Flow Metab Date: 2015-12-17 Impact factor: 6.200