Literature DB >> 12749898

A novel estrogen receptor ligand template.

Robert Sibley1, Holia Hatoum-Mokdad, Robert Schoenleber, Laszlo Musza, William Stirtan, Diana Marrero, William Carley, Hong Xiao, Jacques Dumas.   

Abstract

Three synthetic routes towards a novel estrogen receptor ligand template based on a rigid bicyclo-[3.3.1]-nonene core have been investigated. The prototype compound exhibits potent binding at the ERbeta receptor and promising estrogen receptor subtype selectivity.

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Year:  2003        PMID： 12749898     DOI： 10.1016/s0960-894x(03)00307-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

Authors:  Pengcheng Wang; Jian Min; Jerome C Nwachukwu; Valerie Cavett; Kathryn E Carlson; Pu Guo; Manghong Zhu; Yangfan Zheng; Chune Dong; John A Katzenellenbogen; Kendall W Nettles; Hai-Bing Zhou
Journal:  J Med Chem       Date:  2012-02-21       Impact factor: 7.446

2.  A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling.

Authors:  Chetana M Revankar; Cristian G Bologa; Richard A Pepermans; Geetanjali Sharma; Whitney K Petrie; Sara N Alcon; Angela S Field; Chinnasamy Ramesh; Matthew A Parker; Nikolay P Savchuk; Larry A Sklar; Helen J Hathaway; Jeffrey B Arterburn; Tudor I Oprea; Eric R Prossnitz
Journal:  Cell Chem Biol       Date:  2019-11-06       Impact factor: 8.116

3.  Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

Authors:  Manghong Zhu; Chen Zhang; Jerome C Nwachukwu; Sathish Srinivasan; Valerie Cavett; Yangfan Zheng; Kathryn E Carlson; Chune Dong; John A Katzenellenbogen; Kendall W Nettles; Hai-Bing Zhou
Journal:  Org Biomol Chem       Date:  2012-11-21       Impact factor: 3.876
  3 in total

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