| Literature DB >> 12749892 |
George A Doherty1, Ginger X Yang, Edite Borges, Sharon Tong, Ermengilda D McCauley, Kelly M Treonz, Gail Van Riper, Stephen Pacholok, Qian Si, Gloria C Koo, Kashmira Shah, Richard A Mumford, William K Hagmann.
Abstract
A series of isonicotinoyl-(L)-aminophenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. These compounds exhibit subnanomolar binding affinity to VLA-4 and significant off-rates. The interplay between off-rate, protein binding and pharmacokinetics is discussed.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12749892 DOI： 10.1016/s0960-894x(03)00308-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823