AIMS: To correlate the fluorescein angiographic (FAG) classification in age-related macular degeneration (AMD) with the histology of surgically excised choroidal neovascularization (CNV) membrane specimens. METHODS: 36 subretinal lesions surgically excised during macular translocation were investigated by light microscopy. Histologic results were correlated with fluorescein angiographic findings. RESULTS: Classic CNV lesions showed a subretinal fibrovascular membrane on histological examination. About 50% of the investigated classic CNV lesions had additional subpigment epithelial components, too. Occult CNV lesions showed a subpigment epithelial fibrovascular membrane on histological examination. A common histological component in lesions of exudative age-related macula degeneration was the appearance of diffuse deposits at the choroidal side of the retinal pigment epithelium. CONCLUSION: Different FAG characteristics in exudative AMD lesions were comparable with the histological results. In correspondence with FAG classification the CNV membranes were localized in different positions in relation to the RPE.
AIMS: To correlate the fluorescein angiographic (FAG) classification in age-related macular degeneration (AMD) with the histology of surgically excised choroidal neovascularization (CNV) membrane specimens. METHODS: 36 subretinal lesions surgically excised during macular translocation were investigated by light microscopy. Histologic results were correlated with fluorescein angiographic findings. RESULTS:Classic CNV lesions showed a subretinal fibrovascular membrane on histological examination. About 50% of the investigated classic CNV lesions had additional subpigment epithelial components, too. Occult CNV lesions showed a subpigment epithelial fibrovascular membrane on histological examination. A common histological component in lesions of exudative age-related macula degeneration was the appearance of diffuse deposits at the choroidal side of the retinal pigment epithelium. CONCLUSION: Different FAG characteristics in exudative AMD lesions were comparable with the histological results. In correspondence with FAG classification the CNV membranes were localized in different positions in relation to the RPE.
Authors: Susanna S Park; Steven N Truong; Robert J Zawadzki; Suhail Alam; Stacey S Choi; David G Telander; John S Werner; Lawrence S Morse Journal: Invest Ophthalmol Vis Sci Date: 2010-03-10 Impact factor: 4.799
Authors: A Lommatzsch; P Hermans; K D Müller; N Bornfeld; A C Bird; D Pauleikhoff Journal: Graefes Arch Clin Exp Ophthalmol Date: 2008-04-15 Impact factor: 3.117
Authors: Albrecht Lommatzsch; Pia Hermans; Bernhard Weber; Daniel Pauleikhoff Journal: Graefes Arch Clin Exp Ophthalmol Date: 2007-08-18 Impact factor: 3.117